関連する実験動画

Updated: Jan 8, 2026

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

Published on: January 7, 2019

ウイルス戦士：がん免疫療法における腫瘍溶解性ウイルスの免疫システムポテンシャル解明

Reza Ghavimi^1,2, Leila Rahimian^1,2, Mohsen Mohammadi³

¹Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, USA.

Molecular therapy. Oncology

|December 24, 2025

Abstract:

Oncolytic viruses (OVs) represent an exciting avenue in tumor immunotherapy, harnessing the power of viruses to overcome resistance and enhance immune responses. OVs achieve this by selectively targeting and destroying tumor cells. This cell lysis releases tumor-specific antigens (TAAs), effectively creating an in situ vaccine that educates the immune system. Moreover, OVs directly trigger both innate and adaptive immunity and can be genetically engineered to secrete immune-boosting factors. Early studies have shown promising synergistic antitumor effects when OVs are combined with other cancer therapies or immunotherapies. A key advantage of OVs is their capacity to reprogram the tumor microenvironment (TME), transforming immunologically inert "cold" tumors into actively inflamed "hot" tumors. This environmental shift is crucial for successful immunotherapy, as it allows for increased infiltration of immune cells, particularly cytotoxic T lymphocytes (CTLs), into the tumor. This comprehensive review covers the history, mechanisms, and potential combinatorial strategies involving OVs. It also addresses the challenges faced in their development and highlights current clinical trials exploring their role as potent immunotherapeutic agents.

キーワード:

定期号抗腫瘍免疫がん併用免疫療法がん免疫療法腫瘍溶解性ウイルス標的療法腫瘍

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Genome-wide RNAi Screening to Identify Host Factors That Modulate Oncolytic Virus Therapy

Genome-wide RNAi Screening to Identify Host Factors That Modulate Oncolytic Virus Therapy

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