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Updated: Jan 8, 2026

Non-Viral Engineering of Primary Human T Cells via Homology-Mediated End-Joining Targeted Integration of Large DNA Templates
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Non-Viral Engineering of Primary Human T Cells via Homology-Mediated End-Joining Targeted Integration of Large DNA Templates

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次世代遺伝子治療のためのサイズ制約を克服するプログラム可能な大貨物統合

Lifang Yu1, Mario Andrea Marchisio2

  • 1School of Chemistry and Chemical Engineering, Huangshan University, Huangshan, 245041, PR China.

Synthetic and systems biotechnology
|December 24, 2025
PubMed
まとめ

塩基およびプライムエディターのような新しいゲノム編集ツールは、正確なDNA修飾を可能にします。このレビューは、遺伝子治療における現在の制限を克服するために、大きなDNA断片（> 1 kb）を効率的に挿入する3つの高度なシステムを強調しています。

キーワード:
CASTs臨床療法大規模DNA挿入PEインテグラーゼnCas9-R2

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