クロピドグレル誘発性器質化肺炎の肺生検による評価と偶発的な再投与による確認例

Clopidogrel-induced interstitial lung disease (ILD) is a rare but significant adverse effect. Herein, we report a case of organizing pneumonia following clopidogrel administration, confirmed by histopathology and accidental re-administration, fulfilling Camus's criteria for drug-induced ILD. The patient responded well to corticosteroid therapy. A systematic literature review identified nine additional cases, with clinical presentations ranging from ground-glass opacities to eosinophilic infiltration. Most cases involved immune-mediated mechanisms. This report highlights the diagnostic challenges of clopidogrel-induced ILD and underscores the importance of considering drug etiology in organizing pneumonia.