がん、神経疾患、代謝性疾患、免疫調節における多面的な調節因子であるLRRC8A
Longjun Yang1, Qiang Ding1, Xiaoyu Ji1
1Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Department of Gastroenterology, Wuhan, Hubei 430000, China.
Abstract:
Leucine-rich repeat containing 8A (LRRC8A) is a member of the LRRC8 family, exhibiting broad expression across various tissues and cells in vertebrates. Like other LRRC8 family members, LRRC8A contributes to the formation of volume-regulated anion channels (VRACs), which are crucial for regulating cell volume and maintaining homeostasis. LRRC8A participates in diverse signaling pathways. Multiple studies have validated the links between LRRC8A dysregulation and neurological disorders, metabolic ailments, and tumors. This review provides a comprehensive overview of the regulatory mechanisms of LRRC8A in these pathologies. The primary goal was to assess the potential of LRRC8A as a therapeutic target for treating diseases and address key unresolved issues.
関連する概念動画
lncRNA - Long Non-coding RNAs
Master Transcription Regulators
Neural Regulation
mTOR Signaling and Cancer Progression
The mTOR pathway or the...
Regulation of the Unfolded Protein Response
Regulation of Expression at Multiple Steps

