地図状萎縮（GA）における病変周囲の眼底自家蛍光（FAF）パターンの経時的変化とその進行との関連性

Alessio Antropoli^1,2, Francesco Vacirca^1,2, Ugo Introini^1,2

¹Department of Ophthalmology, IRCCS San Raffaele Scientific Institute, Milan, Italy.

Ophthalmology science

|December 24, 2025

要旨

Purpose:

To investigate cross-sectional characteristics and longitudinal changes in perilesional fundus autofluorescence (FAF) patterns in geographic atrophy (GA).

Study Design:

Retrospective cohort study.

Participants:

One hundred forty-three eyes from 99 patients (70 females) with foveal-sparing GA at baseline, of which 106 eyes from 76 patients were eligible for longitudinal analyses.

Methods:

Best-corrected visual acuity, FAF, and OCT findings were collected at all visits. Baseline FAF patterns were determined using a 5-item classification, with tracking of longitudinal changes. Changes in GA growth rate following pattern transitions were investigated through linear mixed models.

Main Outcome Measures:

Frequency and timing of perilesional FAF pattern transitions, and their association with GA growth rate.

Results:

Of the 106 eyes with follow-up, 23 (22%) showed a change in perilesional FAF pattern after a median of 3 years (interquartile range: 1.74-4.10). Square root GA growth rate was 0.40 mm/year (95% confidence interval [CI]: 0.34-0.46; P < 0.001), with modestly faster rate in "diffuse nontrickling" compared with "none" eyes (+0.06 mm/year; 95% CI: 0.004-0.12; P = 0.036) and slower rate in eyes showing FAF pattern transitions (-0.12 mm/year; 95% CI: -0.19 to -0.05; P < 0.001). Baseline lesion size and other FAF patterns were not significantly associated with progression (P > 0.05).

Conclusions:

Perilesional FAF pattern transitions occur in a subset of GA eyes and are marked by slower progression, underscoring their potential relevance for disease monitoring and clinical trial design.

Financial Disclosures:

Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.

キーワード:

AMD FAFパターン眼底自家蛍光地理的萎縮

さらに関連する動画

08:54

Author Spotlight: Understanding Age-Related Macular Degeneration Pathophysiology with QAF Workflow

Published on: May 26, 2023

2.1K

10:14

Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

Published on: May 26, 2023

4.1K

関連する概念動画

01:18

Models of Health Promotion and Illness Prevention II

The person's health status fluctuates continually, varying from being in good health to becoming ill and returning to being healthy. To understand the concept of illness prevention, there are two models. First, the health-illness continuum model is a graphic representation of an individual's wellness. It states that a person is considered healthy in the absence of physical disease and the presence of good emotional health.
The agent-host-environment model states that disease results from...

01:29

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...

01:16

Focusing of Light in the Eye

Light rays enter the eye through the cornea, a transparent dome-shaped tissue that is the eye's outermost layer. The cornea bends or refracts, light rays traveling to the pupil. The shape of the cornea determines how much of the light is bent and whether the image will be focused correctly on the retina at the back of the eye. Once the light has passed through both refraction layers, it converges into a single focal point onto a small area. This is where photoreceptors start transforming...

01:22

Photoreceptors and Visual Pathways

At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category, whereas...

$Influence of Earth's Curvature and Atmospheric Refraction on Leveling$ 01:26

Influence of Earth's Curvature and Atmospheric Refraction on Leveling

During leveling, the Earth's curvature and atmospheric refraction introduce deviations in the line of sight from a true horizontal reference. When the line of sight is leveled, it remains perpendicular to the plumb line only at a single point. Beyond this, it deviates due to the Earth’s curvature, represented by the correction C. For a sight distance D, the deviation can be derived using the relationship:This relationship shows that the deviation increases quadratically with distance. Over a...