Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Infection01:20

Infection

11.6K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
11.6K
Urinary Tract Infection II: Pathophysiology01:25

Urinary Tract Infection II: Pathophysiology

524
The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
524
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

676
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
676
Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

2.5K
The pathophysiology of pneumonia involves the following steps:
2.5K
Stages of Infection01:26

Stages of Infection

64.7K
Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
64.7K
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

2.6K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
2.6K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Validity of the NINDS traumatic encephalopathy syndrome criteria for predicting chronic traumatic encephalopathy.

medRxiv : the preprint server for health sciences·2026
Same author

Reliability of TRUST ASL for measuring cerebral blood flow and blood-brain barrier water exchange: a scan-rescan pilot study in healthy subjects and patients with epilepsy.

medRxiv : the preprint server for health sciences·2026
Same author

Understanding the contribution of toxicant exposures to Alzheimer's disease and related dementias.

Current opinion in neurobiology·2026
Same author

3D choroidal vascularity index in hyperopic amblyopic eyes of preschool children: a case-control study using SS-OCTA.

International journal of ophthalmology·2026
Same author

Arterial spin labeling MRI with multiple post-labeling delays reveals interictal hypo- and hyper-perfusion patterns in epilepsy: A proof of concept.

Journal of neuroradiology = Journal de neuroradiologie·2026
Same author

Sleep in Epilepsy Special Interest Group | Brain Flow Dynamics and Sleep Alterations Effect on EpilepsyFrom Babies to Late Adults and Breathing to Cognition: The Impact of Sleep on Seizures and Cognitive Function in Epilepsy Through the Lens of Water Exchange Dynamics.

Epilepsy currents·2026
Same journal

Unveiling the procoagulant state in Alzheimer's disease: A novel PET imaging strategy.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Estimated labor market outcomes of people progressing from preclinical to early-stage Alzheimer's disease in the United States.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Amyloid exacerbates tau and alpha-synuclein pathologies, behavioral impairments, and neuroinflammation in a mixed dementia model.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Multimorbidity burden and patterns associated with DeepBrainNet-derived brain-age gap in dementia-free older adults: A community-based study.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Reply to "Shifting the emphasis of brain health literacy from individuals to systems to reduce inequalities".

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Shifting the emphasis of brain health literacy from individuals to systems to reduce inequalities.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
関連記事をすべて見る

関連する実験動画

Updated: Jan 8, 2026

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses
09:07

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses

Published on: June 14, 2020

11.5K

基礎科学と病態生理

Juliet A Moncaster1,2, Elijah Demb2, Olga Minaeva1,2

  • 1Boston University Alzheimer's Disease Research Center, Boston, MA, USA.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
PubMed
まとめ
この要約は機械生成です。

この研究では、マウスの水晶体でタウタンパク質が検出され、P301Sタウ変異モデルでは加工が変化しているものの、カタラクトは形成されないことがわかりました。アミロイドβはアルツハイマー病においてより重要である可能性があります。

キーワード:
タウタンパク質アルツハイマー病マウス水晶体変異カタラクト病態生理遺伝子神経科学眼科

さらに関連する動画

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia
13:45

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia

Published on: September 21, 2019

6.0K
Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses
08:38

Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses

Published on: February 22, 2019

6.3K

関連する実験動画

Last Updated: Jan 8, 2026

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses
09:07

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses

Published on: June 14, 2020

11.5K
A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia
13:45

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia

Published on: September 21, 2019

6.0K
Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses
08:38

Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses

Published on: February 22, 2019

6.3K

科学分野:

  • 眼科; 神経科学; 遺伝学

背景:

  • アルツハイマー病（AD）は、眼の水晶体におけるアミロイドβ（Aβ）の蓄積と関連しています。; AD脳の病態生理に関与するタウタンパク質は、マウスの水晶体における発現が様々に報告されています。

研究 の 目的:

  • 非トランスジェニックマウスおよびP301Sタウ変異マウスの水晶体におけるタウタンパク質の発現を調査する。; タウ変異が白内障フェノタイプと相関するかどうかを判断する。

主な方法:

  • 生涯にわたるP301Sトランスジェニックマウスおよび非トランスジェニックマウスの水晶体からのタウのウェスタンブロット分析。; 白内障形成を評価するための水晶体の肉眼的画像評価。; 対照としてタウノックアウトマウス組織を利用しました。

主要な成果:

  • P301Sトランスジェニックマウスと非トランスジェニックマウスの両方の水晶体でタウタンパク質が検出されました。; P301Sトランスジェニックマウスの水晶体では、ウェスタンブロットで追加のより高分子量のタウバンドが示されました。; どちらのグループのマウスでも白内障フェノタイプは観察されませんでした。

結論:

  • P301Sタウ変異は水晶体におけるタウの加工に影響を与えるようですが、白内障を引き起こすものではありません。; アミロイドβは、アルツハイマー病に関連する水晶体の病態生理において、タウよりも重要な役割を果たしている可能性があります。