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Updated: Jan 7, 2026

Monitoring of Nanodrug Accumulation in Murine Breast Cancer Metastases

Monitoring of Nanodrug Accumulation in Murine Breast Cancer Metastases

Published on: August 23, 2024

乳癌骨転移の形成と進行におけるマイクロRNA：この研究分野における最近の進歩に関する概観

Margherita Puppo¹

¹IRCCS Ospedale Policlinico San Martino, Largo Rosanna Benzi 10, 16132 Genova, Italy.

|December 24, 2025

Abstract:

Bone metastasis is a common and severe complication in advanced stages of breast cancer (BC) that is characterised by limited treatment options and poor patient prognosis. MicroRNAs (miRNAs) are a large class of regulatory small non-coding RNAs (ncRNAs) expressed by cells. Moreover, miRNAs can be released by cells into the blood and lymphatic streams, acting as distant cell-to-cell communicators. Of note, miRNAs have pivotal roles in the metastatic progression of BC to bone. This review summarises the most recent findings on miRNAs and their mRNA targets in driving BC bone metastasis. Furthermore, the potential clinical uses of miRNAs as future therapeutic targets/agents or biomarkers for BC bone metastasis are discussed.

キーワード:

バイオマーカー骨転移乳癌 miR miRNA マイクロRNA ncRNA 骨芽細胞破骨細胞標的療法

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Intra-iliac Artery Injection for Efficient and Selective Modeling of Microscopic Bone Metastasis

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MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as A Novel Detection and Quantification Method

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Published on: October 7, 2025

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