Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Infection01:20

Infection

11.6K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
11.6K
Urinary Tract Infection II: Pathophysiology01:25

Urinary Tract Infection II: Pathophysiology

524
The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
524
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

676
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
676
Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

2.5K
The pathophysiology of pneumonia involves the following steps:
2.5K
Stages of Infection01:26

Stages of Infection

64.7K
Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
64.7K
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

2.6K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
2.6K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Perceptions of Over-the-Counter Hearing Aids: A Qualitative Study Informed by the Technology Acceptance Model.

Journal of the American Academy of Audiology·2026
Same author

A cross-sectional analysis of county-level determinants of pandemic-era policy implementation.

Frontiers in public health·2026
Same author

Prevalence, incidence, and 6-years stability of metabolically unhealthy normal weight́s phenotype in u.s. hispanic/latino adults.

Diabetes research and clinical practice·2026
Same author

Height variation independent of known genetic variants and health in later life: a cohort study.

The American journal of clinical nutrition·2026
Same author

Health of Hispanic/Latino Workers in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) Sociocultural Ancillary Study: Privileges and Disadvantages of Occupational Status and Exposure to Hazards.

Occupational health science·2026
Same author

Modifiable Risk Factors and Socioeconomic Inequity in Diabetes: A Prospective Analysis in the UK Biobank.

Biomedical and environmental sciences : BES·2026
Same journal

Breaking barriers: Enhancing access to dementia clinical trials in the United Kingdom-Insights from the Scientific Advisory Board of the Dame Barbara Windsor Dementia Goals Programme.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Unveiling the procoagulant state in Alzheimer's disease: A novel PET imaging strategy.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Estimated labor market outcomes of people progressing from preclinical to early-stage Alzheimer's disease in the United States.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Amyloid exacerbates tau and alpha-synuclein pathologies, behavioral impairments, and neuroinflammation in a mixed dementia model.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Multimorbidity burden and patterns associated with DeepBrainNet-derived brain-age gap in dementia-free older adults: A community-based study.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Reply to "Shifting the emphasis of brain health literacy from individuals to systems to reduce inequalities".

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
関連記事をすべて見る

関連する実験動画

Updated: Jan 7, 2026

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses
09:07

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses

Published on: June 14, 2020

11.5K

基礎科学と病態生理

Myriam Fornage1, Rui Xia1, Tamar Sofer2,3

  • 1University of Texas Health Science Center at Houston, Houston, TX, USA.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
PubMed
まとめ
この要約は機械生成です。

ヒスパニック/ラテン系成人における脳白質高信号（WMH）の遺伝学的研究により、既知の座位と新規の座位が特定されました。この研究は、WMHの遺伝的構造を理解する上で、多様な集団の重要性を強調しています。

キーワード:
脳白質高信号遺伝率ゲノムワイド関連解析ヒスパニック/ラテン系新規座位

さらに関連する動画

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia
13:45

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia

Published on: September 21, 2019

6.0K
Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses
08:38

Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses

Published on: February 22, 2019

6.3K

関連する実験動画

Last Updated: Jan 7, 2026

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses
09:07

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses

Published on: June 14, 2020

11.5K
A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia
13:45

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia

Published on: September 21, 2019

6.0K
Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses
08:38

Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses

Published on: February 22, 2019

6.3K

科学分野:

  • 神経遺伝学; 集団遺伝学; 医用画像

背景:

  • 脳白質高信号（WMH）は、認知機能低下および認知症と関連しています。; 遺伝学的研究（GWAS）によりWMH座位が同定されていますが、ヒスパニック/ラテン系集団は過小評価されています。; ヒスパニック/ラテン系成人では、非ヒスパニック白人よりもWMHの負担が高いことが示されています。

研究 の 目的:

  • 多様なヒスパニック/ラテン系コホートにおけるWMHの遺伝的構造を特徴づけること。; 既知のWMH遺伝子座の転移可能性を調査すること。; ヒスパニック/ラテン系の遺伝的多様性を活用して、新規のWMH座位を同定すること。

主な方法:

  • 2159人のヒスパニック/ラテン系成人を対象にゲノムワイド関連解析およびアドミクスチャマッピング解析を実施しました。; 以前に同定された27のWMH座位における関連を調査しました。; メタアナリシスでは、ヒスパニック/ラテン系のGWAS結果を、他の集団からの既存のGWASデータと統合しました。

主要な成果:

  • WMHの遺伝率は29%と推定されました。; 27の既知のWMH座位のうち20について、転移可能性の証拠が見つかりました。; マルチアンスリーメタアナリシスおよびアドミクスチャマッピングによって、それぞれ12q22（rs10859915）の新規座位および14q13.2（RALGAPA1）の新規座位が同定されました。

結論:

  • 他の集団で同定されたWMH座位は、ヒスパニック/ラテン系成人に関連があります。; 多様なヒスパニック/ラテン系集団は、既知の座位のファインマッピングおよび新規座位の発見に価値があります。; 本研究は、脳白質高信号の遺伝的構造の理解を深めます。