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デング熱と急性膵炎:システマティックレビュー
Matteo Riccò1, Antonio Cascio2, Luca Pipitò2
1AUSL-IRCCS di Reggio Emilia, Servizio di Prevenzione e Sicurezza Negli Ambienti di Lavoro (SPSAL), Local Health Unit of Reggio Emilia, 42122 Reggio Emilia, Italy.
Tropical medicine and infectious disease
|December 24, 2025
まとめ
デングウイルス(DENV)は急性膵炎、まれな合併症を引き起こす可能性があります。急性壊死性膵炎は急性間質性膵炎よりも重症であり、転帰が悪く、死亡率が高いです。
科学分野:
- 感染症
- 消化器病学
- 公衆衛生
背景:
- デング熱は一般的な発熱性疾患です。
- 急性膵炎は、デングウイルス感染症のまれではあるが重篤な合併症です。
- デングウイルス関連急性膵炎の臨床的特徴および転帰に関するデータは限られています。
研究 の 目的:
- デングウイルス(DENV)関連急性膵炎の臨床スペクトラムを体系的にレビューおよび特徴付けること。
- DENV感染における急性間質性膵炎と急性壊死性膵炎を鑑別すること。
- DENV関連急性膵炎に関連する危険因子および転帰を特定すること。
主な方法:
- PRISMAガイドラインに従ってシステマティックレビューを実施しました。
- PubMed、EMBASE、Scopus、MedRxiv、およびBioRxivで症例報告およびシリーズを検索しました。
- 実験室で確認されたDENV感染および急性膵炎の診断を含む研究を含めました。
主要な成果:
- アジアおよび南米が主な地域であるDENV関連急性膵炎の70例を特定しました。
- 急性間質性膵炎(65.7%)は、急性壊死性膵炎(34.3%)よりも一般的でした。
- 急性壊死性膵炎は、より高い死亡率(25.0%)、多臓器不全、および長期入院と関連していました。
結論:
- デングウイルス関連急性膵炎は臨床的な注意が必要です。
- 急性壊死性膵炎は、より重篤な合併症とより悪い予後を示します。
- 患者の転帰を改善するためには、早期認識と管理が重要です。
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