Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Infection01:20

Infection

11.6K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
11.6K
Urinary Tract Infection II: Pathophysiology01:25

Urinary Tract Infection II: Pathophysiology

524
The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
524
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

676
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
676
Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

2.5K
The pathophysiology of pneumonia involves the following steps:
2.5K
Stages of Infection01:26

Stages of Infection

64.7K
Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
64.7K
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

2.6K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
2.6K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Behavior of neural networks in culture suggest that sporadic and genetic forms of Alzheimer's disease may not be equivalent.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Sperm tRNA-derived fragments: molecular mechanisms and clinical implications for paternal epigenetic inheritance.

Clinical epigenetics·2026
Same author

CDK3 induces neuronal death and brain atrophy in Alzheimer's disease.

Nature aging·2025
Same author

Perimenopausal state oestradiol to progesterone imbalance drives Alzheimer's risk via ERRα dysregulation and energy dyshomeostasis.

Nature communications·2025
Same author

Nuclear BIN1 isoforms regulate c-Myc-mediated cell cycle control in oligodendrocytes.

bioRxiv : the preprint server for biology·2025
Same author

Alpha-ketoglutarate mitigates insulin resistance and metabolic inflexibility in a mouse model of Ataxia-Telangiectasia.

Nature communications·2025

関連する実験動画

Updated: Jan 7, 2026

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses
09:07

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses

Published on: June 14, 2020

11.5K

基礎科学と病態生理

Fulin Ma1, Rody Kingston1, Eliana Brenner1

  • 1University of Pittsburgh, Pittsburgh, PA, USA.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
PubMed
まとめ
この要約は機械生成です。

アルツハイマー病

キーワード:
アルツハイマー病神経変性疾患APPDNA損傷神経保護

さらに関連する動画

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia
13:45

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia

Published on: September 21, 2019

6.0K
Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses
08:38

Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses

Published on: February 22, 2019

6.3K

関連する実験動画

Last Updated: Jan 7, 2026

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses
09:07

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses

Published on: June 14, 2020

11.5K
A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia
13:45

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia

Published on: September 21, 2019

6.0K
Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses
08:38

Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses

Published on: February 22, 2019

6.3K

科学分野:

  • 神経科学; 分子生物学; 遺伝学

背景:

  • アルツハイマー病（AD）は通常65歳以上の個人に影響します。; アミロイド前駆体タンパク質（APP）はAD病態の中心ですが、そのAβ非依存的役割は十分に研究されていません。; この研究では、APPを様々なストレスによって上昇する損傷応答タンパク質と見なしています。

研究 の 目的:

  • アルツハイマー病（AD）におけるDNA損傷とアミロイド前駆体タンパク質（APP）の関係を調査します。; アミロイドβ（Aβ）との関連を超えて、AD病態における全長APPの潜在的な役割を探ります。

主な方法:

  • マウス脳および培養ニューロンに対する免疫細胞化学を使用しました。; 53BP1、γ-H2AX、TUNELアッセイなどのマーカーを使用してDNA損傷を追跡しました。; ヒトAPPの過剰発現およびBACE1/γ-セクレターゼ阻害薬にレンチウイルスを使用し、Aβ産生を調節しました。

主要な成果:

  • 神経興奮と誘発DNA損傷の両方がAPP発現を増加させます。; APPの過剰発現は、ADマウスモデルおよびニューロンにおけるDNA損傷の増加につながります。; Aβ産生の阻害薬はAPP誘発性DNA損傷をブロックしましたが、直接的なAβ適用はブロックしませんでした。これは、APP細胞内ドメイン（AICD）の役割を示唆しています。

結論:

  • 老化の兆候であるDNA損傷とADの兆候であるAPPとの間の双方向の関連を確立しました。; DNA損傷との関連を介して、AD病態における全長APPの新規な役割を特定しました。; AD進行を駆動する可能性のあるAPPとDNA損傷を含むフィードフォワードループメカニズムを提案しました。