臨床症状
Glenda Dias Dos Santos1, Orestes Vicente Forlenza2,3,
1Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
まとめ
COVID-19生存者の15％が認知的障害の影響を受け、入院から24か月後に記憶、注意、言語に影響を与えています。これらの障害を他の神経学的状態と区別するには、早期の特定が重要です。
科学分野:
- Neurology
- Cognitive Science
- Infectious Disease Research
背景:
- COVID-19 survivors frequently report cognitive impairments, leading to functional limitations and reduced quality of life.
- A significant portion of individuals experience persistent cognitive deficits following moderate to severe COVID-19 illness.
研究 の 目的:
- To assess the prevalence and nature of cognitive impairments in a cohort of COVID-19 survivors.
- To investigate long-term cognitive sequelae in individuals who experienced moderate or severe COVID-19.
主な方法:
- 361 adult COVID-19 survivors were evaluated 24 months post-hospital discharge.
- A comprehensive cognitive battery included the Mini Mental State Examination, CERAD battery, Trail Making Test (A and B), and Digit Span test.
主要な成果:
- 15% (54 adults) exhibited cognitive deficits across various domains.
- Impairments were noted in verbal fluency (48.1%), naming (74%), word list recall (83.3%), executive function (Trail Making Test, 66.7%), and working memory (Digit Span, 53.7%).
- Significant correlations were found between cognitive test performance, age, and Mini-Mental State Examination scores.
結論:
- The cognitive battery effectively identified deficits in executive function, memory, attention, and language in COVID-19 survivors.
- Establishing specific cognitive deficit patterns is essential for differentiating COVID-19-related impairments from other dementia types.
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