バイオマーカー
Jacklyn Leonardo1, Gurveen Kaur Sandhu1, Ashwati Vipin2
1Dementia Research Centre (Singapore), Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
まとめ
血管要因は東南アジア人の認知症バイオマーカーに著しく影響し、アミロイド負担、GFAP、NfL、pTau181が高い値を示した。多様な集団における認知症リスクの理解には、地域特異的な研究が不可欠である。
科学分野:
- Neurology; Biomarker Research; Population Health
背景:
- Dementia research predominantly focuses on Western populations, neglecting Southeast Asia's ethnic diversity.
研究 の 目的:
- To investigate demographic, genetic, and cerebral white matter influences on blood-based dementia biomarkers in Singapore.
主な方法:
- Analysis of 1,646 participants from the Biomarker and Cognition Study Singapore (BIOCIS).
主要な成果:
- Fazekas positivity correlated with altered biomarkers in Cognitively Unimpaired individuals (excluding Aβ42/40 ratio).
- In Mild Cognitive Impairment, vascular burden (Fazekas/Staals positivity) linked to elevated GFAP, pTau181, and NfL.
- The BIOCIS MCI cohort exhibited lower amyloid burden and APOE4 positivity but higher white matter hyperintensities compared to Western cohorts.
結論:
- Fazekas positivity influences dementia biomarker profiles in Southeast Asians, emphasizing vascular contributions.
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Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
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