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Updated: Jan 7, 2026

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

臨床症状

Joseph Eichenbaum¹, Miriam T Ashford^1,2, Chengshi Jin¹

¹University of California, San Francisco, San Francisco, CA, USA.

Alzheimer's & dementia : the journal of the Alzheimer's Association

|December 25, 2025

まとめ

この要約は機械生成です。

pTau217およびGFAPなどの血漿バイオマーカーは、高齢者の主観的認知機能低下および記憶の懸念と相関します。この遠隔スクリーニング方法は、アルツハイマー病（AD）のリスクのある個人を特定するのに役立ちます。

キーワード:

アルツハイマー病認知機能低下血漿バイオマーカー pTau217 GFAP 遠隔スクリーニング高齢者

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Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling

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関連する実験動画

Last Updated: Jan 7, 2026

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

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Published on: June 16, 2020

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling

Published on: October 14, 2021

科学分野:

神経学;バイオマーカー発見;老年医学

背景:

血漿バイオマーカーは、アルツハイマー病（AD）の早期検出に有望です。;主観的認知機能低下（SCD）は、AD連続体の早期症候性段階を表します。;SCD集団における血漿バイオマーカーの有用性は十分に調査されていません。

研究の目的:

遠隔コホートにおける血漿ADバイオマーカーレベルと主観的/客観的認知測定との関係を調査すること。;ADスクリーニングおよびモニタリングのためのスケーラブルな遠隔データ収集の可能性を評価すること。

主な方法:

629人の参加者（55歳以上）が、血漿分析のために遠隔採血を受けました。;測定された血漿バイオマーカーには、NFL、Aβ42/40、pTau231、pTau217、およびGFAPが含まれていました。;線形回帰により、バイオマーカーと認知スケール（ECog、記憶の懸念、Cogstate）との関連を分析しました。

主要な成果:

上昇したpTau217およびpTau231レベルは、自己申告による記憶の懸念と相関していました。;より高いpTau217およびGFAPは、ECogスケールでの自己申告による認知機能低下の増加と関連していました。;血漿バイオマーカーと客観的な認知パフォーマンス（Cogstate）との間に有意な関連は見られませんでした。

結論:

SCDおよび記憶の懸念の遠隔、非監督デジタル測定は、上昇した血漿pTauおよびGFAPを持つ個人を特定できます。;このアプローチは、AD関連の認知障害のリスクのある高齢者を効率的に特定します。;スケーラブルな方法は、臨床試験の募集、観察研究、および臨床ケアスクリーニングを容易にします。