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関連する概念動画

Infection01:20

Infection

11.6K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
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Urinary Tract Infection II: Pathophysiology01:25

Urinary Tract Infection II: Pathophysiology

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The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
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Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

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Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
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Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

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The pathophysiology of pneumonia involves the following steps:
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Stages of Infection01:26

Stages of Infection

64.7K
Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
64.7K
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

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The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
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Updated: Jan 7, 2026

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses
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基礎科学と病態生理

Fernanda G Q Barros-Aragão1, Luis E Santos1, Talita Pinto2

  • 1D'Or Institute for Research and Education, Rio de Janeiro, RJ, Brazil.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
PubMed
まとめ
この要約は機械生成です。

COVID-19神経学的患者は、アルツハイマー病（AD）患者と同様にタウタンパク質の上昇を示し、炎症と関連している。COVID-19後の持続的な炎症と認知機能障害は、将来のADリスクを高める可能性がある。

キーワード:
COVID-19アルツハイマー病神経学的症状タウタンパク質炎症認知機能障害バイオマーカーSARS-CoV-2

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A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia
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A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia

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Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses
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Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses

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関連する実験動画

Last Updated: Jan 7, 2026

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses
09:07

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Published on: June 14, 2020

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A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia
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A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia

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Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses
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Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses

Published on: February 22, 2019

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科学分野:

  • Neuroscience; Immunology; Infectious Diseases

背景:

  • COVID-19 can cause neurological symptoms and cognitive decline, with Alzheimer's disease (AD) increasing COVID-19 severity.; Inflammation is implicated in both COVID-19 and AD, suggesting a potential molecular link.; It remains unclear if COVID-19 patients with neurological issues exhibit AD-related molecular changes.

研究 の 目的:

  • To investigate molecular alterations related to Alzheimer's disease (AD) pathology in COVID-19 patients with neurological symptoms.; To identify potential molecular links between COVID-19 and AD for improved patient follow-up and prevention strategies.

主な方法:

  • Retrospective analysis of cerebrospinal fluid (CSF) biomarkers (amyloid-beta, Tau) in controls, mild cognitive impairment, AD, and COVID-19 patients with neurological symptoms.; Correlation of CSF biomarkers with inflammation markers (IL6, SII).; Prospective evaluation of plasma biomarkers (amyloid-beta, Tau) and cognitive outcomes in COVID-19 survivors up to one year post-infection.

主要な成果:

  • COVID-19 patients with neurological symptoms showed elevated CSF Tau at hospitalization, similar to AD patients.; No significant changes in CSF amyloid-beta or pTau-181 levels were detected in COVID-19 patients.; CSF biomarkers and pro-inflammatory cytokines correlated with systemic inflammation (SII).; Plasma Tau/amyloid-beta ratio increased in COVID-19 survivors with cognitive deficits one year post-infection.; Longitudinal plasma Tau changes were influenced by disease severity, inflammation, and cognitive deficits.

結論:

  • Inflammation is a key factor in acute and persistent AD-related molecular changes observed in COVID-19 patients.; COVID-19 survivors with ongoing inflammation or cognitive symptoms require careful monitoring for potential future AD risk.