基礎科学と病態生理
Fernanda G Q Barros-Aragão1, Luis E Santos1, Talita Pinto2
1D'Or Institute for Research and Education, Rio de Janeiro, RJ, Brazil.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
まとめ
COVID-19神経学的患者は、アルツハイマー病（AD）患者と同様にタウタンパク質の上昇を示し、炎症と関連している。COVID-19後の持続的な炎症と認知機能障害は、将来のADリスクを高める可能性がある。
科学分野:
- Neuroscience; Immunology; Infectious Diseases
背景:
- COVID-19 can cause neurological symptoms and cognitive decline, with Alzheimer's disease (AD) increasing COVID-19 severity.; Inflammation is implicated in both COVID-19 and AD, suggesting a potential molecular link.; It remains unclear if COVID-19 patients with neurological issues exhibit AD-related molecular changes.
研究 の 目的:
- To investigate molecular alterations related to Alzheimer's disease (AD) pathology in COVID-19 patients with neurological symptoms.; To identify potential molecular links between COVID-19 and AD for improved patient follow-up and prevention strategies.
主な方法:
- Retrospective analysis of cerebrospinal fluid (CSF) biomarkers (amyloid-beta, Tau) in controls, mild cognitive impairment, AD, and COVID-19 patients with neurological symptoms.; Correlation of CSF biomarkers with inflammation markers (IL6, SII).; Prospective evaluation of plasma biomarkers (amyloid-beta, Tau) and cognitive outcomes in COVID-19 survivors up to one year post-infection.
主要な成果:
- COVID-19 patients with neurological symptoms showed elevated CSF Tau at hospitalization, similar to AD patients.; No significant changes in CSF amyloid-beta or pTau-181 levels were detected in COVID-19 patients.; CSF biomarkers and pro-inflammatory cytokines correlated with systemic inflammation (SII).; Plasma Tau/amyloid-beta ratio increased in COVID-19 survivors with cognitive deficits one year post-infection.; Longitudinal plasma Tau changes were influenced by disease severity, inflammation, and cognitive deficits.
結論:
- Inflammation is a key factor in acute and persistent AD-related molecular changes observed in COVID-19 patients.; COVID-19 survivors with ongoing inflammation or cognitive symptoms require careful monitoring for potential future AD risk.
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