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アルツハイマー病に関連するモノアミン代謝物の変化：5-HIAAおよびHVAの低下、MHPGの上昇。メタアナリシスは神経伝達物質の調節不全を明らかにする。

Muneeb Ahmad Muneer1, Harshita Agarwa2, Poorvikha Gowda3

  • 1Allama Iqbal Medical College, Lahore, Punjab, Pakistan.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
PubMed
まとめ

アルツハイマー病患者では、5-ヒドロキシインドール酢酸（5-HIAA）とホモバニリン酸（HVA）のレベルが低下し、3-メトキシ-4-ヒドロキシフェニルグリコール（MHPG）のレベルが上昇する。これらの所見は、アルツハイマー病（AD）におけるモノアミン神経伝達の変化を示唆している。

キーワード:
アルツハイマー病モノアミン代謝物脳脊髄液神経伝達物質5-HIAAHVAMHPG

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