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Updated: Jan 7, 2026

Author Spotlight: Exploring Cloning Techniques for Full-Length DNA Fragments

Author Spotlight: Exploring Cloning Techniques for Full-Length DNA Fragments

Published on: May 17, 2024

ブタサーコウイルス2型とその関連ウイルスの系統学的解析

Libin Wen^1,2,3,4,5, Han Wen⁶, Qi Xiao^1,2,3,4,5

¹Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Nanjing, China.

Frontiers in veterinary science

|December 25, 2025

要旨

Introduction:

Porcine circovirus (PCV) belongs to the family Circoviridae. Four conventional PCVs (PCV1 to PCV4) have been discovered over time. PCV1 and PCV2 exhibit higher nucleotide identity compared to PCV3 and PCV4. PCV2, in particular, has caused porcine circovirus-associated diseases (PCVAD), posing a significant threat to the global swine industry. Subsequently, unconventional PCVs, including porcine circovirus-like viruses and porcine circovirus-like mini agents, with genome sequences highly homologous to the PCV2 capsid protein sequence, have been reported.

Methods:

This advancement facilitates phylogenetic analysis of these sequences to elucidate the evolutionary history of PCV2, although its true origin remains undetermined.

Results And Discussion:

Based on the findings, it is speculated that PCV2 may have originated from ancestral non-coding DNA sequences. This speculation provides new insights into the evolutionary question of which nucleic acid and protein first emerged.

キーワード:

PCV2 祖先配列進化的ブタサーコウイルス様ミニエージェントブタサーコウイルス様ウイルス

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