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Updated: Jan 7, 2026

Microfluidic On-chip Capture-cycloaddition Reaction to Reversibly Immobilize Small Molecules or Multi-component Structures for Biosensor Applications
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Microfluidic On-chip Capture-cycloaddition Reaction to Reversibly Immobilize Small Molecules or Multi-component Structures for Biosensor Applications

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低分子免疫センシングのためのタンパク質競合因子のデノボ設計

Yosta de Stigter1,2, Tallie Godschalk1,2, Maarten Merkx1,2

  • 1Laboratory of Chemical Biology, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands.

bioRxiv : the preprint server for biology
|December 25, 2025
PubMed
まとめ

ディープラーニングモデルは、時間のかかる化学合成に取って代わる競合イムノアッセイ用のタンパク質結合因子を迅速に設計します。これらの新規結合因子は、ジゴキシンなどの低分子をバイオセンサーで高感度に検出することを可能にします。

キーワード:
de novo protein designbiosensorsimmunoassaysprotein engineeringdeep learningsmall molecule detectiondigoxin

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