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関連する概念動画

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

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In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
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Liver Physiology01:30

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The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of  70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
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Liver Histology01:27

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The microscopic anatomy of the liver is a complex and intricate system that comprises numerous structural units known as liver lobules, each of which is comparable in size to a sesame seed. These hexagonal structures consist of plates of liver cells or hepatocytes, which are characterized by their versatility and abundance of cellular apparatus like rough and smooth ER, Golgi apparatus, peroxisomes, and mitochondria.
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Serum Studies: Renal Function Tests01:24

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Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
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Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow01:26

Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow

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Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug...
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Liver Regeneration01:24

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The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
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Updated: Jan 7, 2026

A Small Animal Model of Ex Vivo Normothermic Liver Perfusion
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肝機能検査の「正常」を定義する

Priscilla Chong1, Dhanushan Gnanendran1, Yu Xiang Gao-Du1

  • 1Gastroenterology, York and Scarborough Teaching Hospitals NHS Foundation Trust, Scarborough, GBR.

Cureus
|December 25, 2025
PubMed
まとめ
この要約は機械生成です。

標準的な肝機能検査（LFT）では、結果が正常であっても、多くの肝硬変のケースを見逃す可能性があります。早期発見には、包括的な患者評価のためにLFTを超えたより広範なアプローチが必要です。

キーワード:
慢性肝疾患診断の限界早期発見LFT - 肝機能検査肝硬変

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Functional Human Liver Preservation and Recovery by Means of Subnormothermic Machine Perfusion
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Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro
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Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro

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関連する実験動画

Last Updated: Jan 7, 2026

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Functional Human Liver Preservation and Recovery by Means of Subnormothermic Machine Perfusion
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Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro
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科学分野:

  • 肝臓病学; 内科学; 診断医学

背景:

  • 慢性肝疾患の診断は、肝硬変が発症するまでしばしば遅れます。標準的な肝機能検査（LFT）は、著しい肝機能障害があるにもかかわらず正常に見えることがあります。肝硬変の早期特定は、適時の介入のために非常に重要です。

研究 の 目的:

  • 肝硬変患者における肝機能検査（LFT）、血液学的パラメータ、および臨床的因子の分析を目的としました。肝硬変の特定におけるLFTの診断的有用性を評価しました。代償性肝疾患におけるLFTの限界を理解しました。

主な方法:

  • 確認された肝硬変患者251人を対象とした後向き観察研究。LFT、全血球計算、国際正規化比（INR）、およびアルブミン-ビリルビン（ALBI）スコアを含めました。LFTが正常な患者と異常な患者を比較するサブグループ分析を実施しました。

主要な成果:

  • 肝硬変患者の37%でLFTが正常でした。これは、臨床的関連所見がない場合には48%に上昇しました。アルブミン-ビリルビン（ALBI）スコアは、全患者の59.1%、およびLFT正常群の83.3%で正常でした。血清AST/ALT比の上昇がコホートで観察されました。

結論:

  • 標準的なLFTのみでは、かなりの割合の肝硬変患者を診断するには不十分です。代償性肝硬変は正常なLFTで現れる可能性があり、検査の限界を強調しています。早期の肝硬変検出には、臨床指標と非侵襲的ツールを統合した多因子アプローチが必要です。