妊娠週数と先天性心疾患との関連における環境微粒子状物質への週次母体曝露

The association between maternal exposure to air pollution and congenital heart diseases (CHDs) has garnered increasing attention. However, investigations into critical weekly specific exposure windows for CHDs remain limited. This study evaluated the relationship between maternal ambient particulate matter exposure throughout the entire pregnancy period and the risk of CHDs, as well as explored critical weekly specific exposure windows.

Based on the Jiangsu Maternal and Child Health Monitoring Manual and the Environmental Health Department of Suzhou CDC, 19,914 pregnant women with complete hospital delivery records between 2021 and 2023 were included, and the concentration data for five air pollutants (PM₁₀, PM_2.5, NO₂, CO, and SO₂) in Suzhou City from 2020 to 2023 were obtained in this study. Distributed lag models (DLMs) incorporated in Cox proportional-hazards models were applied to assess the exposure-lag-response relationship between the weekly average exposure levels during pregnancy and the risk of CHDs, identifying the refined exposure windows.

A 10 μg/m³ increase in maternal exposure to PM₁₀ was positively associated with CHDs during gestational weeks 5-12 and weeks 18-22 (p < 0.05). The strongest association was observed in gestational weeks 5 and 6 (HR, 1.010; 95% CI, 1.000-1.020; HR, 1.010; 95% CI, 1.002-1.017). The association between maternal exposure to PM_2.5 and the risk of CHDs was not observed during all gestational weeks.

Our study results demonstrate that exposure to high concentrations of PM₁₀ increases the risk of CHDs, with susceptible exposure windows identified as gestational weeks 5-12 and weeks 18-22. Our study provides further evidence supporting the association between maternal exposure to ambient particulate matter and CHDs while also identifying critical windows. However, further studies are required to confirm these findings.