関連する実験動画
Updated: Jan 7, 2026

05:12
Transoral Endoscopic Thyroidectomy Vestibular Approach for Thyroid Lobectomy
Published on: May 12, 2023
4.6K
甲状腺ホルモン製剤(レボチロキシン)過剰投与による甲状腺機能亢進症および術前スクリーニング評価における高ビリルビン血症
Carly J Suriano1, Ian P Erkkila1, Thomas M Vara2
1Department of General Surgery, OhioHealth Riverside Methodist Hospital, Columbus, Ohio, USA, ohiohealth.com.
Case reports in endocrinology
|December 25, 2025
まとめ
レボチロキシン過剰投与は肝障害を引き起こす可能性がある。レボチロキシン(甲状腺ホルモン補充療法薬)の用量を調整することで、肝酵素異常が改善し、薬剤の安全な継続使用が可能になる。
科学分野:
- 肝臓学
- 内分泌学
- 薬理学
背景:
- レボチロキシンは甲状腺機能低下症の標準治療である。
- レボチロキシンによる肝障害は稀と考えられている。
- 本症例では、レボチロキシン関連肝機能障害を検討する。
研究 の 目的:
- レボチロキシン誘発性肝障害の症例報告。
- 用量調整による肝機能障害の改善を実証すること。
- レボチロキシンの継続使用の可能性を強調すること。
主な方法:
- 60歳男性の症例報告。
- 術前クリアランスのための評価。
- 肝機能障害および甲状腺機能亢進症の検査。
- レボチロキシン過剰投与の診断。
主要な成果:
- 患者は甲状腺機能亢進症に伴う肝機能障害を呈した。
- 上昇した肝酵素は、肝細胞性と胆汁うっ滞性の混合パターンを示した。
- レボチロキシンの用量を減らした後、肝酵素は正常化した。
結論:
- レボチロキシン過剰投与は肝機能障害を引き起こす可能性がある。
- 肝障害の症例では、薬剤誘発性甲状腺機能亢進症を考慮すべきである。
- 用量調整後、レボチロキシンは安全に継続できる。
関連する概念動画
Synthesis and Regulation of Thyroid Hormones
7.0K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
7.0K
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test
165
In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
165
Radiological Investigation I: X-ray and CT
1.0K
Radiological investigations, including X-rays and computed tomography (CT) scans, are critical for diagnosing and evaluating various medical conditions. These imaging techniques provide valuable insights into the body's internal structures, aiding in the detection of abnormalities, assessment of disease progression, and development of treatment strategies. This article delves into two primary radiological investigations, chest X-rays and CT scans, outlining their purpose, procedures, and...
1.0K
Endoscopic Studies II: Thoracocentesis
1.2K
Thoracentesis(Thoracocentesis), commonly known as pleural tap, is a medical procedure where a 22 gauge needle is inserted into the pleural space, the area between the lung and chest wall. This procedure is commonly performed to diagnose or treat various respiratory disorders.
Description
Excess pleural fluid or air may accumulate in some respiratory disorders in the thoracic cavity. To treat pleural effusion, a physician conducts thoracentesis by carefully piercing the chest wall and entering...
Description
Excess pleural fluid or air may accumulate in some respiratory disorders in the thoracic cavity. To treat pleural effusion, a physician conducts thoracentesis by carefully piercing the chest wall and entering...
1.2K

