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関連する概念動画

Preclinical Development: Overview01:28

Preclinical Development: Overview

5.7K
Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
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Clinical Trials: Overview01:11

Clinical Trials: Overview

4.5K
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
4.5K
Drug Discovery: Overview01:26

Drug Discovery: Overview

10.9K
Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
10.9K
Drug Administration and Therapy Phases: Overview01:26

Drug Administration and Therapy Phases: Overview

1.1K
Drugs, the chemical agents used in diagnosing, treating, or preventing diseases, undergo a four-phase process of development: pharmaceutic, pharmacokinetics, pharmacodynamics, and therapeutic.
The pharmaceutical phase focuses on leveraging the physicochemical properties of the drug to design and manufacture an effective product. Variants include orally administered tablets or capsules, topical creams or ointments, and parenteral-delivery solutions or emulsions.
The pharmacokinetic phase...
1.1K
In Vitro Drug Release Testing: Overview, Development and Validation01:10

In Vitro Drug Release Testing: Overview, Development and Validation

269
In vitro dissolution and drug release tests assess how quickly and how much of a drug is released from its dosage form into an aqueous medium under standardized laboratory conditions. These tests are essential tools in pharmaceutical development and quality assurance, offering insight into the drug's performance before clinical use.During formulation development, dissolution testing identifies incomplete or inconsistent drug release issues. It also supports decisions on selecting the optimal...
269
Drug Regulation01:25

Drug Regulation

2.7K
Drug regulation encompasses the management of drug usage by evaluating its safety and efficacy through assessments conducted by regulatory authorities. Regrettably, the history of drug regulation is marred by several catastrophic events. One such incident is the Elixir Sulfanilamide tragedy, in which the toxic compound diethyl glycol was included in a sweet-tasting medication, leading to numerous fatalities. This event prompted the enactment of the Food, Drug, and Cosmetic Act in 1938. Under...
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Updated: Jan 7, 2026

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
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Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

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薬物開発

Folasewa Maryam Abdulsalam1, Orit Shefi Neuro-Engineering Research Lab1

  • 1Bar-Ilan University, Ramat-Gan, Tel-Aviv, Israel.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
PubMed
まとめ

この研究は、アルツハイマー病の改善を目的とした安全な血液脳関門（BBB）破壊のための音響マイクロバブルをモデル化しています。

科学分野:

  • 神経科学; 生体医工学; 薬理学

背景:

  • 血液脳関門（BBB）は、特にアルツハイマー病治療のための脳標的薬物送達における主要な障害です。
  • 音響駆動マイクロバブルは、一時的なBBB開口のための有望なアプローチを提供し、標的治療薬の送達を促進します。

研究 の 目的:

  • 一時的かつ制御された血液脳関門（BBB）破壊のための音響マイクロバブルの使用を調査すること。
  • 潜在的な組織損傷を最小限に抑えながら、効果的なBBB開口のための条件を最適化すること。
  • アルツハイマー病のような神経疾患のための薬物送達戦略を進歩させること。

主な方法:

  • COMSOL Multiphysicsにおけるインシリコモデルの開発と利用。
  • マイクロバブルと音波の相互作用およびBBB透過性への影響のシミュレーション。
  • 音圧下での流体構造相互作用をモデル化するための材料特性と境界条件の割り当て。

主要な成果:

  • 予備的なシミュレーションは、生理学的制約を満たすためのモデルパラメータの洗練に焦点を当てています。
  • この研究は、マイクロバブル誘発性のBBB開口のための特定の条件を特定することを目的としています。
  • BBB破壊中の副組織損傷を最小限に抑えるための努力が向けられています。

さらに関連する動画

In Vitro Three-Dimensional Sprouting Assay of Angiogenesis Using Mouse Embryonic Stem Cells for Vascular Disease Modeling and Drug Testing
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Developmental Toxicity Assay Based on Real-Time Monitoring of Fibroblast Growth Factor Signal Disruption in Human Induced Pluripotent Stem Cells
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関連する実験動画

Last Updated: Jan 7, 2026

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
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Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

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In Vitro Three-Dimensional Sprouting Assay of Angiogenesis Using Mouse Embryonic Stem Cells for Vascular Disease Modeling and Drug Testing
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Developmental Toxicity Assay Based on Real-Time Monitoring of Fibroblast Growth Factor Signal Disruption in Human Induced Pluripotent Stem Cells

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結論:

  • この研究は、安全かつ正確なBBB破壊のためのパラメータに関する重要な洞察をもたらすと予想されます。
  • 調査結果は、アルツハイマー病のための強化された薬物送達システムの開発に貢献します。
  • この研究は、中枢神経系における治療介入の改善の可能性を秘めています。