Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Infection01:20

Infection

11.6K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
11.6K
Urinary Tract Infection II: Pathophysiology01:25

Urinary Tract Infection II: Pathophysiology

521
The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
521
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

674
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
674
Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

2.5K
The pathophysiology of pneumonia involves the following steps:
2.5K
Stages of Infection01:26

Stages of Infection

64.7K
Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
64.7K
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

2.6K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
2.6K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Comorbidity sequence, sex, and APOE-genotype forecast Alzheimer's disease diagnosis.

Frontiers in medicine·2026
Same author

APOE4 accelerates menopause-associated brain metabolic shift and disrupts bioenergetic adaptation.

Frontiers in aging neuroscience·2026
Same author

Anti-inflammatory and immunomodulatory therapies are associated with reduced risk of age-associated neurodegenerative diseases: impact of sex and treatment duration.

Frontiers in aging neuroscience·2026
Same author

Addition of humanized APP to humanized <i>APOE</i> mouse model reduces brain size and increases the ratio of cortical representation.

bioRxiv : the preprint server for biology·2026
Same author

Meta analysis of glucose metabolism across Alzheimer's, Parkinson's and ALS Reveals emergence of adaptive brain glucometabolic responses and associated neurological functional profiles.

medRxiv : the preprint server for health sciences·2026
Same author

Premenopausal bilateral oophorectomy leads to steeper declines in gray matter volume and alterations in perfusion and brain bioenergetics.

Scientific reports·2026

関連する実験動画

Updated: Jan 7, 2026

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses
09:07

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses

Published on: June 14, 2020

11.5K

基礎科学と病態生理

Mikaila Ann Bantugan1, Roberta Diaz Brinton1

  • 1University of Arizona, Tucson, AZ, USA.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
PubMed
まとめ

APOE4遺伝子変異を持つメスのマウスは、cGAS-STING経路を介して神経炎症とミトコンドリア機能不全が増加し、アルツハイマー病のリスクが高いことを示唆している。

科学分野:

  • 神経科学
  • 遺伝学
  • 免疫学

背景:

  • ミトコンドリア機能不全と神経炎症は、アルツハイマー病（AD）の早期徴候である。
  • 自然免疫に関与するcGAS-STING経路は、ADの病態生理において役割を果たす。
  • APOE4遺伝子型と女性の性は、cGAS-STINGシグナル伝達を介してミトコンドリア機能不全と神経炎症を悪化させる可能性がある。

研究 の 目的:

  • ミトコンドリア機能不全と神経炎症における性別およびAPOE特異的な関連を調査する。
  • これらのプロセスにおけるcGAS-STING経路の役割を、ADの遺伝的リスクモデルで調べる。

主な方法:

  • 18ヶ月齢のヒト化APPおよびAPOE3/3またはAPOE4/4マウスを使用した。
  • 海馬組織のバルクRNAシーケンシング（RNA-seq）を用いた。
  • 遺伝子セット濃縮解析、Ingenuity Pathway Analysis、免疫組織化学、ウェスタンブロット法を用いて、経路とシグナル伝達を評価した。

主要な成果:

  • メスのhAPP/hAPOE4マウスは、オスと比較して、神経炎症、cGAS-STINGシグナル伝達、およびミトコンドリア機能不全が高かった。
  • hAPP/hAPOE3マウスでは、性差はそれほど顕著ではなかった。
キーワード:
アルツハイマー病神経炎症ミトコンドリア機能不全cGAS-STING経路APOE4性差

さらに関連する動画

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia
13:45

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia

Published on: September 21, 2019

6.0K
Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses
08:38

Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses

Published on: February 22, 2019

6.3K

関連する実験動画

Last Updated: Jan 7, 2026

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses
09:07

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses

Published on: June 14, 2020

11.5K
A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia
13:45

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia

Published on: September 21, 2019

6.0K
Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses
08:38

Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses

Published on: February 22, 2019

6.3K
  • 有意な性別-APOE遺伝子型相互作用が、神経炎症、ミトコンドリア機能不全、およびcGAS-STINGシグナル伝達に影響を与えた。

    • 結論:

    • 神経炎症およびミトコンドリア経路における一貫した性差が観察された。
    • APOE遺伝子型は神経炎症シグネチャに影響を与え、特にメスで顕著であった。
    • メスのhAPP/hAPOE4マウスにおけるcGAS-STINGシグナル伝達の亢進は、女性のADリスクを高める可能性があり、AD研究において性別と遺伝子型を考慮する必要性を強調する。