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Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
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臨床症状

Yanxing Chen1, Siyan Zhong1, Xinyi Zhang1

  • 1Department of Neurology, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.

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PubMed
まとめ
この要約は機械生成です。

リアルワールドデータによると、中国における早期アルツハイマー病（AD）に対するレカネマブ治療は、早期無症候性のアミロイド関連画像異常（ARIA）につながった。この抗アミロイド抗体療法の管理には早期モニタリングが不可欠である。

キーワード:
レカネマブアルツハイマー病リアルワールドARIA中国

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科学分野:

  • 神経学; 薬理学

背景:

  • 抗アミロイド抗体であるレカネマブは、現在中国でアルツハイマー病（AD）治療に利用可能である。; 中国の人口におけるレカネマブ使用に関するリアルワールドデータは限られている。; 本研究は、中国東部でレカネマブ治療を受けた早期AD患者からの初期所見を報告する。

研究 の 目的:

  • 中国の早期アルツハイマー病患者におけるレカネマブのリアルワールドでの有効性と安全性を評価すること。; レカネマブ治療中のアミロイド関連画像異常（ARIA）の発生率と特徴を評価すること。

主な方法:

  • レカネマブを投与された早期AD患者からの前向きデータ収集。; 患者選択およびARIA管理のための適切な使用推奨事項の遵守。; 点滴反応およびARIA発生のモニタリング。

主要な成果:

  • 60人の患者のうち、13人が点滴反応（発熱、発疹、頭痛、不眠症）を経験した。; 少なくとも5回の点滴を受けた42人の患者のうち4人でARIAが検出された。すべての症例は無症候性であった。; ARIAは早期に発生し、5回目および7回目の点滴前に症例が特定された。

結論:

  • レカネマブ治療に関連するアミロイド関連画像異常（ARIA）は早期に発生する傾向がある。; このコホートにおけるARIA症例の大部分は無症候性であり、注意深いモニタリングの必要性を強調している。; これらの所見は、レカネマブを投与されている患者の臨床実践における早期モニタリングの重要性を支持する。