臨床症状
Sarah Prieto1,2, Molly Split1, Alyssa N De Vito3,4
1Alpert Medical School of Brown University, Providence, RI, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
まとめ
日々のストレス変動は高齢者の認知機能に影響を与える。ストレスが高いほど視覚的ワーキングメモリが向上し、特にアミロイドベータ陽性者で顕著であったが、処理速度は低下した。
科学分野:
- 認知神経科学
- 老年医学
- 心理学
背景:
- 従来のストレスと高齢者の認知機能障害の研究は、集団間の比較を用いて行われてきた。
- スマートフォンベースの評価により、ストレスと認知の個人内変動の分析が可能になる。
- アミロイドベータ(Aβ)の状態がストレスと認知の関係に影響を与える可能性がある。
主な方法:
- 認知機能正常な成人123名(60〜81歳)が、8日間にわたりスマートフォンベースの認知タスク(処理速度、視覚的ワーキングメモリ、エピソード記憶)を毎日実施した。
- 参加者は、M2C2アプリを通じて、各認知評価の直前のストレスレベルを報告した。
- 多層モデリングにより、個人内ストレスとセッション数の間の相互作用を分析し、Aβ PETイメージングの結果に基づいて探索的分析を行った。
結論:
- 個体内ストレスの変動は、遠隔モニタリング中の認知機能に有意に影響を与える。
- ストレスの増加は処理速度を低下させる可能性があるが、特にAβ+の個人では視覚的ワーキングメモリを向上させる可能性がある。
- ストレス誘発性の注意資源の変化が、特定の領域における認知機能の変動を説明する可能性がある。
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