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基礎科学と病態生理

Quan Vo1, Dina Nacionales1, Kristi Biswas1

  • 1University of Florida, Gainesville, FL, USA.

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まとめ
この要約は機械生成です。

全身性炎症はアルツハイマー病（AD）のマウスモデルにおいてタウ病理を加速しなかった。しかし、敗血症は雄と雌のマウスで寿命と脳内タウレベルに異なる影響を及ぼした。

キーワード:
全身性炎症アルツハイマー病タウ病理マウスモデル性差敗血症寿命免疫応答

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科学分野:

  • 神経科学；免疫学；病理学

背景:

  • 炎症はアルツハイマー病（AD）の神経変性の重要な要因である。；これまでの研究では、脳内炎症がADモデルにおけるタウ病理に影響することが示されている。；慢性的な末梢性炎症が脳内タウに及ぼす影響は不明なままである。

研究 の 目的:

  • 慢性的な末梢性炎症が脳内タウタンパク質を変化させるかどうかを調査する。；PS19マウスにおける敗血症がタウ病理および免疫応答に及ぼす影響を調べる。

主な方法:

  • PS19マウス（ヒトP301S変異タウのトランスジェニックマウス）に腹腔内敗血症および慢性ストレスを誘発した。；免疫組織化学およびフローサイトメトリーのために脳および脾臓組織を採取した。；前駆症状および生存コホートにおけるリン酸化タウ（AT8）および免疫細胞の変化を評価した。

主要な成果:

  • 全身性炎症は、どちらの性でもAT8陽性タウ病理を加速しなかった。；敗血症は免疫細胞の分布を変化させ、メスではCD8+ T細胞の減少、両性で骨髄由来抑制細胞の増加が認められた。；寿命と領域別AT8-タウ負荷量に性差が観察され、敗血症を呈した雄マウスでは海馬タウが低かった。

結論:

  • 全身性炎症は、アルツハイマー病マウスモデルにおいて、性別に依存した様式で寿命および領域別タウ負荷量に影響を与える可能性がある。；全身性炎症とAD型タウ病理との間のメカニズム的関連を解明するには、さらなる研究が必要である。