Jove
Visualize
お問い合わせ

関連する概念動画

Infection01:20

Infection

11.6K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
11.6K
Urinary Tract Infection II: Pathophysiology01:25

Urinary Tract Infection II: Pathophysiology

521
The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
521
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

674
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
674
Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

2.5K
The pathophysiology of pneumonia involves the following steps:
2.5K
Stages of Infection01:26

Stages of Infection

64.7K
Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
64.7K
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

2.6K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
2.6K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Dose-response and cumulative effects of educational attainment and occupational complexity on mid to late life cognitive performance in Brazil and Mexico.

Alzheimer's & dementia. Behavior & socioeconomics of aging·2026
Same author

Multilocus Sequence Typing Reveals New Insights into the Population Structure and Genetic Diversity of <i>Lactococcus</i> spp. from Brazilian Fish.

Microorganisms·2026
Same author

Resilience to neuronal hyperactivity and restoration of the neuroimmune interactome by blocking fibrin-induced microglia activation in Alzheimers disease.

bioRxiv : the preprint server for biology·2026
Same author

Ultraprocessed Foods and the Aging Brain: State of the Science.

Annual review of nutrition·2026
Same author

Association Between Alcohol Consumption, Cognitive Abilities, and Neuropathologic Changes: A Population-Based Autopsy Study.

Neurology·2026
Same author

Undiagnosed dementia and mortality among older adults in the United States and Brazil: A cross-national cohort study.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Evidence for progressive neurodegeneration in iatrogenic cerebral amyloid angiopathy.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Human brain connectome profiles mediate the relationship between pathology burden and clinical phenotypes in Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Kat5 cKO mouse replicates biological domain signatures associated with Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Evaluation of CSF and plasma tau species as fluid surrogate candidates for tau PET in prodromal to moderate Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Associations of self-reported obstructive sleep apnea with cognition and dementia risk in cognitively unimpaired middle-aged adults.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Inflammation profiles in Alzheimer's disease relate to cognition and neurodegeneration.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
関連記事をすべて見る
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する実験動画

Updated: Jan 7, 2026

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses
09:07

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses

Published on: June 14, 2020

11.5K

基礎科学と病態生理

Alexander V Soloviev1, Felipe Luiz Pereira1, Renata Elaine Paraizo Leite2,3

  • 1Memory and Aging Center, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
PubMed
まとめ
この要約は機械生成です。

研究者らは、アルツハイマー病（AD）における脆弱性のあるRORBニューロンと抵抗性のあるRORBニューロンの分子差を特定した。これらの所見は、海馬傍回において、選択的なニューロンの脆弱性を説明し、将来のAD治療を導く可能性がある。

キーワード:
アルツハイマー病海馬傍回ニューロン脆弱性抵抗性RORBタウトランスクリプトーム遺伝子発現神経科学

さらに関連する動画

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia
13:45

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia

Published on: September 21, 2019

6.0K
Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses
08:38

Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses

Published on: February 22, 2019

6.3K

関連する実験動画

Last Updated: Jan 7, 2026

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses
09:07

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses

Published on: June 14, 2020

11.5K
A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia
13:45

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia

Published on: September 21, 2019

6.0K
Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses
08:38

Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses

Published on: February 22, 2019

6.3K

科学分野:

  • 神経科学
  • ゲノミクス
  • 分子生物学

背景:

  • アルツハイマー病（AD）は、特に海馬傍回（EC）のRORB陽性興奮性ニューロンにおける選択的なニューロンの脆弱性を特徴とする。
  • この選択的な脆弱性の分子基盤を理解することは、標的としたAD治療法を開発するために不可欠である。
  • すべてのRORB陽性ニューロンが脆弱性を示すわけではなく、サブタイプ間の内在的な分子差が示唆される。

研究 の 目的:

  • ADの早期段階における、脆弱性のあるRORB陽性興奮性ニューロンサブタイプと抵抗性のあるRORB陽性興奮性ニューロンサブタイプを区別する分子経路を特定すること。
  • 単一核RNAシーケンシング（snRNA-seq）データを活用して、ADにおけるニューロンの脆弱性に関連する転写シグネチャを明らかにすること。

主な方法:

  • 健常対照群およびAD患者の死後EC組織からのsnRNA-seqデータの解析。
  • Braak病期全体にわたる細胞状態の進行をマッピングするためにMonocle3軌道解析を利用。
  • 抵抗性（Q1）および脆弱性（Q4）のRORBニューロントランスクリプトームを比較する差次的遺伝子発現（DEG）解析を実施。

主要な成果:

  • ECにおいて2つの異なるRORB陽性ニューロン集団を特定した。
  • 抵抗性のあるRORBニューロンと脆弱性のあるRORBニューロンの間で537の差次的発現遺伝子を発見した。
  • 脆弱性のあるニューロンでは、超分子繊維形成における経路が上方制御され、タンパク質翻訳および品質管理における経路が下方制御されていた。

結論:

  • 転写シグネチャは、初期ADにおけるRORBニューロンの脆弱性の重要な要因として、細胞骨格形成およびプロテオスタシスに関与する経路を強調している。
  • これらの分子差は、ADにおけるタウ蓄積およびニューロン喪失の根底にある可能性がある。
  • これらのRORBサブポピュレーションのさらなる調査は、ADにおける選択的なニューロン脆弱性メカニズムの理解を洗練させる可能性がある。