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Infection01:20

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When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
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Urinary Tract Infection II: Pathophysiology01:25

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Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
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Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
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基礎科学と病態生理

Renata Elaine Paraizo Leite1, Lea T Grinberg1,2, Vitor Ribeiro Paes1

  • 1University of Sao Paulo Medical School, São Paulo, Brazil.

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PubMed
まとめ
この要約は機械生成です。

中年成人における神経精神症状（NPS）は脳病変と関連している。ラクナ梗塞などの血管病変は、興奮、易怒性、妄想と関連しており、早期疾患におけるその役割を示唆している。

キーワード:
脳病変神経精神症状中年成人神経変性疾患早期マーカー

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科学分野:

  • 神経病理学; 神経精神医学; 神経変性疾患

背景:

  • 神経精神症状（NPS）は神経変性疾患に蔓延しており、認知機能低下に先行することがあります。若い成人および中年成人における神経病理学的病変とNPSとの関連を理解することは、早期疾患マーカーを特定するために重要です。

研究 の 目的:

  • 30〜64歳の成人における特定の神経病理学的基質と一般的なNPSとの関連を調査すること。この年齢層における認知状態に関連したNPSの有病率を調査すること。

主な方法:

  • 413人（30〜64歳）の集団ベースの死後研究。神経病理（NFT、アミロイドβ、レビー小体、TDP-43、梗塞、CAA、動脈硬化症）およびNPS（神経精神医学的調査票）を評価した。調整済みモデルを使用して、神経病理と7つのNPSの関係を評価し、認知状態（CDR）に基づくNPSの頻度を比較した。

主要な成果:

  • 認知機能障害のある個人ではNPSがより一般的でした。うつ病と不安は神経原線維変化（NFT）の病期と相関していました。不安は脳アミロイド血管症（CAA）と関連していました。興奮、易怒性、妄想はラクナ梗塞と関連していました。

結論:

  • 血管病変は、特定の神経精神症状と有意な関係を示しました。本研究の結果は、血管病理が中年成人におけるNPSの要因となる可能性を強調しています。