プロトコル：Logicaを用いた異種集団間局所的遺伝相関の推定

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Updated: May 12, 2026

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations

Published on: November 3, 2010

Boran Gao¹, Zheng Li², Xiang Zhou³

¹Department of Statistics, Purdue University, West Lafayette, IN 47907, USA; Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA.

|December 25, 2025

Abstract:

Here, we present a reproducible protocol for estimating cross-ancestry local genetic correlation using Logica, a likelihood-based framework that employs summary statistics from genome-wide association studies (GWASs) and ancestry-specific linkage disequilibrium (LD). We describe steps for estimating locus-level heritability and cross-ancestry genetic correlation and outlining required inputs. We then detail analytical procedures to enable accurate and scalable inference of shared genetic architecture. For complete details on the use and execution of this protocol, please refer to Gao et al.¹.

キーワード:

バイオインフォマティクス計算科学遺伝学ゲノミクス健康科学

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Large-Scale Multi-Omics Genome-Wide Association Studies (Mo-GWAS): Guidelines for Sample Preparation and Normalization

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Published on: July 27, 2021

CorrelationCalculator and Filigree: Tools for Data-Driven Network Analysis of Metabolomics Data

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