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Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

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Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
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Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

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Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
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Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

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Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
358
Heart Failure III: Clinical Manifestations01:26

Heart Failure III: Clinical Manifestations

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Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
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Gastroesophageal Reflux Disease II: Clinical Features and Management01:29

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Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
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Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

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Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
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A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
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臨床症状

Jennifer A Frontera1, Arjun V Masurkar1,2,3, Alok Vedvyas1,2,3

  • 1NYU Grossman School of Medicine, New York, NY, USA.

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まとめ

後遺症のCOVID-19の患者は、そうでない患者と比較して、著しく認知機能が悪く、アルツハイマー型を含む軽度認知障害（MCI）の有病率が高いことを示しています。これは、SARS-CoV-2感染の持続的な神経学的影響を強調しています。

キーワード:
後遺症のCOVID-19軽度認知障害認知機能アルツハイマー型神経学的影響

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科学分野:

  • 神経科学、感染症、老年医学

背景:

  • 後遺症のCOVID-19患者と対照群の神経精神医学的転帰を比較したデータは限られている。COVID-19の長期的な後遺症を理解するためには、認知の違いを調査することが重要である。

研究 の 目的:

  • 後遺症のCOVID-19患者とそうでない患者の神経精神医学的検査結果を比較する。後遺症のCOVID-19と認知障害の診断との関連を決定する。

主な方法:

  • COVID-19陽性（COV+）患者と陰性（COV-）患者を比較した横断研究。神経精神医学的検査のために、ウェストインディーズ大学認知症スクリーニングスケール3（UDS3）を使用した。医師によるコンセンサス診断（正常、MCI、認知症）は、後遺症のCOVID-19の有無に関係なく盲検下で行われた。

主要な成果:

  • 後遺症のCOVID-19患者は、対照群（46%）と比較して、著しく悪い認知テスト結果（64%）を示し、CDRスコア（26% vs. 6%）も高かった。後遺症のCOVID-19患者の25%が軽度認知障害（MCI）または認知症の診断を受け、後遺症のCOVID-19のない患者では6%であった。後遺症のCOVID-19は、特にアルツハイマー型MCI（aOR 4.4）のMCIのオッズ増加と関連していた。

結論:

  • 後遺症のCOVID-19は、より悪い認知パフォーマンスと軽度認知障害の有病率の増加に関連している。アルツハイマー型MCIは、後遺症のCOVID-19症状を経験している個人において有意に一般的である。後遺症のCOVID-19関連の認知低下のメカニズムを解明するためには、さらなる研究が必要である。