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Updated: Jan 7, 2026

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Published on: December 11, 2016

薬物開発

JiMin Kim^1,2, Dohui Ku^1,2, InWook Park^1,2

¹Yonsei Institute of Pharmaceutical Sciences, Incheon, Incheon, Korea, Republic of (South).

Alzheimer's & dementia : the journal of the Alzheimer's Association

|December 25, 2025

要旨

Background:

Abnormal accumulation of amyloid-β (Aβ) aggregates in the brain is a prominent pathology in Alzheimer's disease (AD). This phenomenon is strongly associated with cognitive deficits resulting from neuroinflammation and synaptic dysfunction. Recent studies in AD therapeutics development have highlighted the prospect of reducing amyloid burden in treating AD patients as a promising treatment strategy, prompting the development of small molecule drugs capable of inducing chemical dissociation and clearance of Aβ.

Method:

Herein, we synthesized a chemical library of new chemical entities and selected a compound, IK-9j, that demonstrated profound Aβ clearance efficacy via thioflavin T assays and dot blot analyses. The potential therapeutic efficacy of IK-9j was evaluated utilizing an Aβ42-infused mouse model.

Result:

The IK-9j-treated group exhibited significantly higher levels of short- and long-term memory compared to the non-treated group.

Conclusion:

Collectively, these results underscore the potential of IK-9j as a novel small-molecule therapeutic to mitigate Aβ-associated cognitive deficits in AD.

キーワード:

アルツハイマー病 IK-9j アミロイドβ 低分子化合物マウスモデル記憶改善神経変性疾患創薬

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