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Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

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Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
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Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

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Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
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Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

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Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
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Heart Failure III: Clinical Manifestations01:26

Heart Failure III: Clinical Manifestations

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Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
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Gastroesophageal Reflux Disease II: Clinical Features and Management01:29

Gastroesophageal Reflux Disease II: Clinical Features and Management

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Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
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Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

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Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
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臨床症状

Nancy E Ortega1,2, Judy Pa3,4, Yonggand Shi5

  • 1Alzheimer's Disease Cooperative Study (ADCS), University of California San Diego, La Jolla, CA, USA.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 26, 2025
PubMed
まとめ
この要約は機械生成です。

無関心やうつ病などの神経精神症状は、常染色体優性早期発症アルツハイマー病（ADAD）のリスクがある個人における特定の脳タウ病理に関連しています。この研究は、ADADにおける行動変化に関連するタウ蓄積の地域的特徴を強調しています。

キーワード:
神経精神症状タウ病理常染色体優性早期発症アルツハイマー病PSEN1APPPETイメージング脳

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科学分野:

  • Neuroscience; Neuropathology; Genetics

背景:

  • Investigating the link between neuropsychiatric symptoms and tau pathology in vivo.; Focusing on a cohort at risk for Autosomal Dominant Early Onset Alzheimer's disease (ADAD) due to PSEN1 and APP gene mutations.; Primarily including participants of Mexican ancestry.

研究 の 目的:

  • To characterize the relationship between neuropsychiatric symptoms and in vivo tau pathology.; To examine regional associations of tau PET standard uptake value ratios (SUVrs) with Neuropsychiatric Inventory (NPI) scores.; To explore lateralization effects of these associations within each hemisphere.

主な方法:

  • Utilized data from the Estudio de la Enfermedad de Alzheimer's en Jaliscienses (EEAJ) cohort.; Included participants with or at risk for PSEN1/APP mutations and sporadic late-onset Alzheimer's disease (LOAD).; Employed linear regression models adjusted for relevant demographic and genetic factors, controlling for false discovery rate.

主要な成果:

  • Aberrant motor disturbances correlated with tau pathology in the entorhinal cortex and temporal pole.; Apathy showed a significant relationship with tau pathology in the left posterior cingulate cortex.; Depression was associated with tau in the superior frontal gyrus and left posterior cingulate cortex; irritability linked to left entorhinal cortex and right frontal pole.

結論:

  • Neuropsychiatric symptoms are significantly associated with regional tau pathology in ADAD.; Findings underscore the connection between specific behavioral changes and localized tau accumulation in PSEN1/APP mutation carriers.; This study provides in vivo evidence linking neuropsychiatric manifestations to tau burden in early-onset Alzheimer's disease.