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Updated: Jan 7, 2026

Use of Capillary Electrophoresis Immunoassay to Search for Potential Biomarkers of Amyotrophic Lateral Sclerosis in Human Platelets
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Use of Capillary Electrophoresis Immunoassay to Search for Potential Biomarkers of Amyotrophic Lateral Sclerosis in Human Platelets

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筋萎縮性側索硬化症における神経線維軽鎖プロテオフォームは脳脊髄液と血液で異なる

John B Coulton1,2, Yingxin He1,2, Melissa M Budelier3,4

  • 1Department of Neurology, Washington University in St. Louis, St. Louis, MO.

Annals of neurology
|December 27, 2025
PubMed

キーワード:
神経線維軽鎖プロテオフォーム筋萎縮性側索硬化症バイオマーカー脳脊髄液血液

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Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
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Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
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