免疫調節性線維性スキャフォールドは、二重の酵素模倣活性により術後腫瘍再発を予防する

Surgical resection remains the frontline treatment for solid tumors. However, postsurgical recurrence driven by residual tumor cells and an immunosuppressive microenvironment continues to challenge long-term survival. Here, we propose an implantable fibrous scaffold functionalized with MnO_x nanozymes to prevent tumor recurrence. The dual enzyme-mimic activities of the MnO_x nanozymes endow the scaffold with immunomodulatory functions. On one hand, the MnO_x nanozymes with peroxidase-like activity catalyze the formation of cytotoxic hydroxyl radicals to trigger immunogenic cell death and antigen release. On the other hand, the catalase-like activity helps alleviate hypoxia by decomposing H₂O₂ to O₂, thereby reprogramming macrophages toward a pro-inflammatory M1 phenotype. Concurrently, the released Mn²⁺ ions serve as a potent immune adjuvant, promoting immune cell recruitment and activation. The coordinated immunomodulatory cascade enables the scaffold to establish a sustained local immune niche. Both in vitro and in vivo evaluations confirm that this MnO_x-functionalized scaffold elicits robust antitumor immunity, effectively preventing postsurgical recurrence without exogenous immunostimulants. This work highlights a material-based immunotherapeutic strategy that leverages the intrinsic catalytic and immunomodulatory properties of nanozymes to engineer bioactive scaffolds for postoperative cancer treatment.