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Updated: Jan 7, 2026

Measuring G-protein-coupled Receptor Signaling via Radio-labeled GTP Binding
10:13

Measuring G-protein-coupled Receptor Signaling via Radio-labeled GTP Binding

Published on: June 9, 2017

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Gタンパク質結合受容体のシグナル伝達における内在的に乱れたドメインの役割

Jun Xu1, Ruoyi Qiu1, Alexander M Garces2

  • 1Department of Molecular and Cellular Physiology, Stanford University School of Medicine, 279 Campus Drive, Stanford, California 94305, United States.

Journal of the American Chemical Society
|December 27, 2025
PubMed
まとめ

アルファ2Aアドレネルゲン受容体 (α2AAR) の活性化には,そのトランスメブラン領域と乱れた領域におけるユニークなダイナミクスが含まれています. これらの発見は,多様なシグナリングと潜在的な治療開発に不可欠なアゴニスト特有の構造変化を明らかにします.

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