関連する実験動画

Updated: Jan 7, 2026

Experimental Endocarditis Model of Methicillin Resistant Staphylococcus aureus MRSA in Rat

Experimental Endocarditis Model of Methicillin Resistant Staphylococcus aureus MRSA in Rat

Published on: June 4, 2012

コアグラーゼ陰性ブドウ球菌による菌血症患者における感染性心内膜炎のリスク。多施設共同後ろ向きコホート研究

Virgile Zimmermann¹, Nicolas Fourré¹, Bruno Ledergerber²

¹Infectious Diseases Service, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.

European journal of internal medicine

|December 28, 2025

要旨

Background:

Infective endocarditis (IE) is a serious and under-recognized complication of coagulase-negative staphylococci (CoNS) bacteraemia. The aim was to identify predictors of IE in patients with CoNS bacteraemia and to compare the diagnostic performance of different Duke criteria versions.

Methods:

We retrospectively included adult patients with CoNS bacteraemia (January 2015-June 2024) from two Swiss university hospitals. Each episode was classified according to the 2015 European Society of Cardiology (ESC), 2023 ESC, and 2023 International Society of Cardiovascular Infectious Diseases (ISCVID) Duke criteria. IE diagnoses were established by the Endocarditis Teams or expert clinicians.

Results:

Among 466 episodes, Staphylococcus epidermidis was the most frequent pathogen (360; 77 %), followed by S. lugdunensis (47; 10 %). IE was diagnosed in 106 (23 %) episodes. Multivariable logistic regression identified non-nosocomial acquisition (aOR 6.43; 95 % CI 2.97-13.9), presence of intracardiac prosthetic material (15.4; 6.77-34.8), sepsis (2.34; 1.10-5.00), S. lugdunensis (2.99; 1.06-8.43), persistent bacteraemia for ≥48 h (6.88; 3.14-15.1), and embolic events (58.3; 21.2-160.5) as predictors of IE. The 2023 Duke-ISCVID criteria demonstrated the highest sensitivity (76 %) but lower specificity (61 %) than the 2015 Duke-ESC (sensitivity 21 %, specificity 98 %) and 2023 Duke-ESC (sensitivity 25 %, specificity 96 %) criteria.

Conclusions:

In episodes with CoNS bacteraemia, IE should be strongly suspected in those with persistent bacteraemia, prosthetic intracardiac material, non-nosocomial onset, S. lugdunensis bacteraemia, embolic complications. While the 2023 ISCVID criteria improve sensitivity, their lower specificity highlights the need for further refinement of diagnostic algorithms.

キーワード:

コアグラーゼ陰性ブドウ球菌塞栓イベントデューク基準感染性心内膜炎人工弁ブドウ球菌（Staphylococcus epidermidis）

さらに関連する動画

An In Vitro Model of a Parallel-Plate Perfusion System to Study Bacterial Adherence to Graft Tissues

An In Vitro Model of a Parallel-Plate Perfusion System to Study Bacterial Adherence to Graft Tissues

Published on: January 7, 2019

Visualization of Streptococcus pneumoniae within Cardiac Microlesions and Subsequent Cardiac Remodeling

Visualization of Streptococcus pneumoniae within Cardiac Microlesions and Subsequent Cardiac Remodeling

Published on: April 7, 2015

関連する概念動画

Endocarditis I: Introduction

Endocarditis I: Introduction

Introduction:Endocarditis is the infection of the endocardium, the inner lining of the heart and its valves. When the heart muscle is involved, the condition is termed myocarditis, while an infection of the outer lining is called pericarditis. Infective endocarditis (IE) primarily affects the endocardium, where pathogens adhere to the valves or lining, forming vegetation that can lead to severe complications. Infective endocarditis occurs when microorganisms, usually bacteria from other body...

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...

Endocarditis III: Medical Management

Endocarditis III: Medical Management

Infective endocarditis management involves a multifaceted approach encompassing infection prevention, lifestyle modifications, pharmacological therapy, and surgical management.Infection Prevention:Hand Hygiene: Thorough handwashing is crucial to prevent the spread of infection. Hand hygiene should be performed regularly, especially before and after using the restroom.Oral Hygiene: Good oral hygiene is essential. It includes brushing teeth immediately after waking up and before bed, flossing...

Endocarditis IV: Nursing Management

Endocarditis IV: Nursing Management

Infective endocarditis (IE) is a chronic infection of the heart's endocardium, primarily affecting the heart valves. A detailed nursing assessment for a patient with IE involves collecting subjective and objective data to ensure an accurate diagnosis and timely intervention.Subjective DataThe nurse gathers information about the patient's symptoms and complaints during the subjective assessment. Patients with infective endocarditis often report non-specific symptoms that can mimic other...

Factors Affecting the Risk of Infection

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...

Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic

Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic

Healthcare-associated infections (HAIs) occur in a healthcare facility while a person receives care for another ailment. This category also includes work-related infections among healthcare staff.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies.