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Updated: Jan 7, 2026

Evaluating Cell Death Using Cell-Free Supernatant of Probiotics in Three-Dimensional Spheroid Cultures of Colorectal Cancer Cells

Evaluating Cell Death Using Cell-Free Supernatant of Probiotics in Three-Dimensional Spheroid Cultures of Colorectal Cancer Cells

Published on: June 13, 2020

がん治療におけるプロバイオティクスと生活の質の向上

Himani Muniyal Jheetay¹, Nikhil Menia², Kishore Chandra Thakur³

¹Department of Biochemistry, GEIMS, Dehradun, Uttrakhand, India.

|December 30, 2025

Abstract:

Gastrointestinal toxicity and mental fatigue are common with cancer therapy by reducing patient quality of life. In this observational study patients taking Lactobacillus probiotic had better role function (6.52 vs 6.20, p=0.016), emotional balance (11.96 vs 11.58, p=0.020) and cognitive clarity (6.42 vs 6.20, p=0.037) after 6 weeks. Diarrhoea severity was lower (0.78 vs 1.26, p<0.001) and fewer needed rescue loperamide (24% vs 44%, p=0.034). Thus, we show probiotics help patients adapt better to treatment stress and protect gut-brain axis during chemotherapy and radiotherapy.

キーワード:

ラクトバチルスプロバイオティクスがん治療生活の質

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An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota

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