腸内細菌叢の多様性と高血圧重症度における民族差に関する横断研究

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Updated: Jan 7, 2026

Separation and Differential Characterization of Gut Microbial Extracellular Vesicles in Salt-Sensitive Rats under High-Salt Diet Conditions

Separation and Differential Characterization of Gut Microbial Extracellular Vesicles in Salt-Sensitive Rats under High-Salt Diet Conditions

Published on: June 6, 2025

Rajput Nixitsinh Arvindssinh¹, Tanvi Ghanshyambhai Patel², M R Madan Karthik Raj³

¹Department of Physiology, Junior Resident at GMERS Gotri Medical College and Hospital, Vadodara, Gujarat, India.

|December 30, 2025

Abstract:

Stool samples were analyzed using 16S rRNA sequencing and blood pressure measurements were categorized per AHA guidelines. Hence, 130 adults from three ethnic groups to assess differences in gut microbiome diversity and their association with hypertension severity were studied. Significant ethnic variations were observed in microbial composition, particularly in Firmicutes-to-Bacteroidetes ratios. Greater microbial diversity was associated with lower hypertension severity in certain ethnicities. Thus, we show ethnic-specific microbiome patterns may influence hypertension outcomes.

キーワード:

16S rRNAシーケンシング腸内細菌叢民族差高血圧微生物多様性

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Murine Fecal Isolation and Microbiota Transplantation

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Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

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