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Updated: Jan 7, 2026

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis

Published on: February 10, 2015

血清胆汁酸と肝硬変の重症度との相関：症例対照研究

Soham Doshi¹, Pratibha Sonawane¹, Uditkumar Agrawal²

¹Department of General Medicine, Government Medical College and Maharashtra Post Graduate Institute of Education And Research MUHS, Nashik, Maharashtra, India.

|December 30, 2025

Abstract:

The association of serum bile acid levels with liver cirrhosis severity is of interest. Hence, 100 patients were admitted, among them 50 patients had variable severity of liver cirrhosis and 50 patients were controls. Serum bile acid levels were measured and their association was also analyzed with clinical parameters like Child-Pugh score, MELD score and liver function tests. The results indicate that serum bile acid concentrations are strongly associated with the severity of liver cirrhosis and potentially as a disease progression biomarker. Thus, the clinical value of bile acids as a marker for the severity of liver cirrhosis is shown.

キーワード:

MELDスコア血清胆汁酸バイオマーカー Child-Pughスコア疾患進行肝硬変肝機能検査

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A Mouse Model of Chronic Liver Fibrosis for the Study of Biliary Atresia

A Mouse Model of Chronic Liver Fibrosis for the Study of Biliary Atresia

Published on: February 3, 2023

Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport

Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport

Published on: November 27, 2016

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