リチウム関連甲状腺機能亢進症によるカタトニア
Junting Liu1, Yufei Dai1, Dima Diab1,2
1Division of Endocrinology, Diabetes and Metabolism, University of Cincinnati College of Medicine, Cincinnati, Ohio.
AACE endocrinology and diabetes
|December 30, 2025
まとめ
リチウム関連甲状腺機能亢進症は患者にカタトニアを引き起こす可能性がある。この症例報告で示されたように、リチウムの中止と高カルシウム血症の管理は回復に不可欠である。
科学分野:
- 神経科学
- 内分泌学
- 精神医学
背景:
- リチウムは双極性障害の一般的な治療法である。
- リチウムは甲状腺機能亢進症を引き起こし、カルシウム値の上昇につながる可能性がある。
- 甲状腺機能亢進症は、神経学的障害を含む様々な症状で現れる可能性がある。
研究 の 目的:
- リチウム関連甲状腺機能亢進症によって誘発されたカタトニアのまれな症例を報告すること。
- この病状に関連する診断および管理の課題を強調すること。
- リチウムの使用、甲状腺機能亢進症、およびカタトニアの潜在的な関連を強調すること。
主な方法:
- リチウムを服用中の双極性障害の62歳女性の症例報告。
- 検査結果によって確認されたリチウム誘発性甲状腺機能亢進症の診断。
- 血清カルシウム値およびカタトニアの臨床症状のモニタリング。
主要な成果:
- 患者は血清カルシウム値のピークが12.1 mg/dLのカタトニアを発症した。
- ロラゼパムおよび電気けいれん療法にもかかわらずカタトニアは持続した。
- リチウムの中止とゾレドロン酸の投与により、カルシウム値の低下と臨床的改善につながった。
結論:
- カタトニアを呈する患者では、リチウム誘発性甲状腺機能亢進症を考慮すべきである。
- 高カルシウム血症の早期認識と管理は、患者の回復にとって不可欠である。
- この症例は、長期リチウム療法を受けている患者における副甲状腺機能のモニタリングの重要性を強調している。
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