非造血系マイクロRNA-26b-/-は、内皮細胞の炎症と白血球接着を増加させることにより、アテローム性動脈硬化症の発症を増強する
Linsey J F Peters1, Kiril Bidzhekov1, Remco T A Megens1,2,3
1Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-University Munich, Germany (L.J.F.P., K.B., R.T.A.M., Y.J., M.H., C.W., Y.D., E.P.C.v.d.V.).
Background:
Atherosclerosis is a leading cause of cardiovascular diseases, and microRNA-26b (miR-26b) has emerged as a significant regulator in its development. This study investigates the role of nonhematopoietic miR-26b in atherosclerosis.
Methods:
To study the specific role of nonhematopoietic cell miR-26b in atherosclerosis development, we used a reverse bone marrow transplantation model combined with 12-week Western-type diet feeding.
Results:
Nonhematopoietic-specific miR-26b deficiency exacerbated atherosclerosis, characterized by larger plaques with increased collagen and necrotic core content. Enhanced VCAM-1 (vascular cell adhesion molecule 1) expression correlated with elevated leukocyte adhesion in ex vivo perfusion studies. Restoration of miR-26b levels in human coronary artery endothelial cells reduced inflammatory responses and leukocyte adhesion.
Conclusions:
Our findings highlight that nonhematopoietic miR-26b plays a protective role in atherosclerosis by modulating endothelial cell function, suggesting potential therapeutic applications for miR-26b mimics in cardiovascular disease management.
関連する概念動画
01:38Inflammation
01:30Atherosclerosis I: Introduction