関連する実験動画
Updated: Jan 7, 2026

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
エストラゴール由来の新規チオセミカルバゾン誘導体の設計、合成、および抗菌評価
Achraf Abdou1, Fatima Ezzahra Maaghloud1, Said Rammali2,3
1Laboratory of Organic Chemistry, Materials, Electrochemistry, and Environment, Faculty of Sciences Ain Chock, Hassan II University, Casablanca, Morocco.
Abstract:
Estragole (p-allylanisole) is a phenylpropene compound found in several aromatic plants and commonly extracted from the essential oil of fennel (Foeniculum vulgare Mill.). This study aimed to synthesise new chalcone derivatives from estragole to explore potential antimicrobial and antioxidant agents. Estragole was oxidised with potassium permanganate (KMnO4) to yield its corresponding aldehyde, acid, and diol derivatives. The aldehyde derivative was further reacted with thiosemicarbazide to form two chalcone-based thiosemicarbazone derivatives. These synthesised compounds are proposed to possess enhanced bioactive properties, suggesting their potential as new bioactive agents.
関連する概念動画
Diels–Alder Reaction Forming Bridged Bicyclic Products: Stereochemistry
Preparation and Reactions of Sulfides
Aryldiazonium Salts to Azo Dyes: Diazo Coupling
Synthesis of α-Substituted Carbonyl Compounds: The Stork Enamine Reaction
Structure-Activity Relationships and Drug Design
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence...

