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Receptor-mediated Endocytosis01:39

Receptor-mediated Endocytosis

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Receptor-mediated Endocytosis01:20

Receptor-mediated Endocytosis

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Receptor-mediated endocytosis is when bulk amounts of specific molecules are imported into a cell after binding to cell surface receptors. The molecules bound to these receptors are taken into the cell through inward folding of the cell surface membrane, which is eventually pinched off into a vesicle within the cell. Structural proteins, such as clathrin, coat the budding vesicle.
Clathrin-Mediated Endocytosis of LDL
One well-characterized example of receptor-mediated endocytosis is the...
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Adherens Junctions01:24

Adherens Junctions

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Strong contact points between adjacent cells anchor them to each other, forming tissues. Such anchoring junctions are of two types –  adherens junctions and desmosomes. Adherens junctions are abundant in tissues such as  epithelium and endothelium, forming a continuous zone of adhesion called the adhesion belt. In other tissues, such as  heart muscle, they appear as clusters, linking the cells to produce coordinated heart muscle contraction.
Adherens Junctions are Dynamic
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Transducer Mechanism: Enzyme-Linked Receptors01:27

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Intracellular Movement of Viruses and Bacteria01:10

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Intracellular bacteria and viruses often comprise a group of highly infectious pathogens that can cause several diseases. Bacterial pathogens include those belonging to the genus Rickettsia responsible for conditions such as rocky mountain spotted fever and the Mediterranean spotted fever; Chlamydia, a genus responsible for a sexually transmitted disease; Coxiella burnetii, an agent responsible for Q fever. Viral pathogens include vaccinia—a poxvirus, and herpes simplex virus—a...
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Immunoglobulin-like Cell Adhesion Molecules01:31

Immunoglobulin-like Cell Adhesion Molecules

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Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
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Enterovirus D68受容体利用：静的付着から動的侵入まで

Dongxue Liu1,2, Zhilin Ji3, Xiangyu Zheng4,5

  • 1Institute of Virology and AIDS Research, The First Hospital of Jilin University, Changchun, Jilin, China.

Journal of virology
|December 30, 2025
PubMed
まとめ

Enterovirus D68（EV-D68）は、細胞に感染するためにSialic acid、ICAM-5、MFSD6を含む複数の受容体を使用します。この受容体の可塑性は、呼吸器系および神経系におけるその広がりを説明し、新しい治療法の開発を導きます。

キーワード:
ICAM-5MFSD6急性弛緩性脊髄炎エンテロウイルスD68シアル酸ウイルス侵入ウイルス受容体

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科学分野:

  • ウイルス学
  • 分子生物学
  • 免疫学

背景:

  • Enterovirus D68（EV-D68）は、重度の呼吸器疾患および急性弛緩性脊髄炎（AFM）を引き起こす再興感染症です。
  • ウイルス侵入メカニズムは、EV-D68の向性および病原性の理解の鍵となります。
  • 以前のモデルはシアル酸に焦点を当てていましたが、最近の発見により、より複雑な受容体ランドスケープが明らかになりました。

研究 の 目的:

  • EV-D68受容体利用に関する進化する理解をレビューすること。
  • ウイルスの付着因子および侵入受容体に関する現在の知識を統合すること。
  • 受容体の多様性がウイルスの進化および治療戦略に与える影響を探ること。

主な方法:

  • EV-D68受容体相互作用に関する研究の文献レビュー。
  • 確立されたおよび新たに同定されたウイルス受容体の分析。
  • 異なる細胞タイプにおける受容体使用の機能的重要性についての議論。

主要な成果:

  • シアル酸は、古いEV-D68株の付着因子および脱殻トリガーとして機能します。
  • ICAM-5は、AFMにおける神経向性を説明する神経特異的受容体です。
  • MFSD6は、呼吸器および神経細胞における多様なEV-D68株の重要な侵入受容体として同定されています。

結論:

  • EV-D68は、シアル酸、ICAM-5、およびMFSD6を利用する顕著な受容体可塑性を示します。
  • この適応性は、組織向性、ウイルスの進化、および疾患の発現に影響を与えます。
  • 受容体-ウイルス相互作用、特にMFSD6インターフェースの理解は、新規EV-D68治療薬の開発にとって重要です。