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Updated: Apr 30, 2026

Development of Amelogenin-chitosan Hydrogel for In Vitro Enamel Regrowth with a Dense Interface

Development of Amelogenin-chitosan Hydrogel for In Vitro Enamel Regrowth with a Dense Interface

Published on: July 10, 2014

虫歯影響下の象牙質におけるユニバーサル歯科用接着剤の界面改善：亜鉛華および銅ナノ粒子含有、2年間in vitro研究

Mario Felipe Gutiérrez^1,2, Romina Aliaga-Gálvez¹, Romina Ñaupari-Villasante³

¹Centro de Investigación e Innovación Biomédica (CIIB), Universidad de los Andes, Chile. Facultad de Odontología, Santiago, Chile.

Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.]

|December 30, 2025

要旨

Objective:

To evaluate the effect of adding zinc oxide and copper nanoparticles (ZnO/CuNp) into universal adhesives (UAs) on resin-dentin microtensile bond strength (μTBS), nanoleakage (NL), and presence of ZnO/Cu within the hybrid layer on caries-affected dentin, both at baseline (T0) and after 2 years of water storage (T2).

Materials And Methods:

ZnO/CuNp (0% [control]; 5/0.1 and 5/0.2 wt%) were added into Prime&Bond Active (PBA) and Ambar Universal (AMB). Ninety-six extracted human third molars were used. After microbiological induction of caries-affected dentin, UAs were applied in both etch-and-rinse and self-etch modes, followed by composite build-up. Specimens were sectioned to obtain resin-caries-affected dentin bonded sticks for μTBS, NL, and chemical characterization of the hybrid layer for Cu and Zn detection at T0 and T2. Data were statistically analyzed (α = 0.05).

Results:

ZnO/CuNp had no effect on μTBS at T0 (p > 0.05) but improved μTBS at T2, compared to control (p < 0.05). Both UAs showed a significant decrease in μTBS over time (p < 0.05), except PBA with ZnO/CuNp in etch-and-rinse mode. NL was significantly lower in ZnO/CuNp-containing UAs at both time points (p < 0.05), though all groups showed increased NL over time. ZnO/CuNp remained detectable in the hybrid layer at T2.

Conclusions:

Adding ZnO/CuNp to UAs decreased adhesive interface degradation on caries-affected dentin, likely due to their presence within the hybrid layer even after 2 years.

Clinical Significance:

ZnO/Cu nanoparticles into UAs could enhance the stability of adhesive restorations on caries-affected dentin by reducing interface degradation.

キーワード:

虫歯象牙質銅マイクロ引張接着強度ナノ漏洩ナノ粒子ユニバーサル接着システム酸化亜鉛

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