関連する実験動画

Updated: May 3, 2026

A Controlled Mouse Model for Neonatal Polymicrobial Sepsis

A Controlled Mouse Model for Neonatal Polymicrobial Sepsis

Published on: January 27, 2019

妊娠中の母親のSARS-CoV-2に関連する新生児多系統炎症性症候群（MIS-N）：単一施設での経験

Cansu Sivrikaya Yildirim¹, Hilal Ozkan², Kevser Ustun Elmas²

¹Department of Pediatrics, Division of Neonatology Gorukle, Bursa Uludag University Medical Faculty, Bursa, Nilufer, 16059, Turkey. cansusivrikaya@uludag.edu.tr.

|December 30, 2025

要旨

Objectives:

Neonatal Multisystem Inflammatory Syndrome (MIS-N) is believed to result either from the transplacental transfer of maternal SARS-CoV-2 antibodies or from a delayed hyperinflammatory response triggered by the neonate's own immune reaction to SARS-CoV-2 infection. In this study we aim to explore the clinical presentation, laboratory findings, and current approaches to the diagnosis and management of MIS-N in neonates.

Material And Method:

A total of 15 infants with MIS-N followed in Bursa Uludag University Neonatal Intensive Care Unit between January 2022 and January 2023 were included in this retrospective study.

Results:

Eight mothers had a history of COVID-19 disease during pregnancy. All of neonates had cardiac involvement (supraventricular tachycardia, persistant sinusal bradycardia or AV block) and 10 infants had respiratory failure. All infants had elevated inflammatory biomarkers and received steroids or/and IVIG. Two infants died.

Conclusion:

The common presentation of MIS-N included cardiac aritmia and respiratory failure. Newborns with MIS-N may be at higher risk for adverse outcomes. Early diagnosis and treatment are important in these patients.

キーワード:

抗SARS-CoV-2抗体 COVID-19 多系統炎症性症候群新生児

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Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using PolyI:C to Study Susceptibility and Resilience in Offspring

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