前立腺がんにおける顆粒球コロニー刺激因子関連大動脈炎の成功例

Shota Yamada¹, Kota Amamoto², Nobuhide Maekawa²

¹Department of Urology Nagasaki University Graduate School of Biomedical Sciences Nagasaki Japan.

IJU case reports

|December 31, 2025

要旨

Introduction:

The frequency of granulocyte colony-stimulating factor-related aortitis is low. We report a case of successful corticosteroid treatment in a patient with prostate cancer who developed aortitis following pegfilgrastim administration.

Case Presentation:

A 68-year-old male with castration-resistant prostate cancer initiated docetaxel therapy. During the second cycle, pegfilgrastim was administered for neutropenia prophylaxis. On Day 10, the patient developed a persistent fever and elevated inflammatory markers. Evaluation led to a diagnosis of granulocyte colony-stimulating factor-related aortitis, and corticosteroid therapy was started. After switching from pegfilgrastim to filgrastim, the patient completed eight treatment cycles without recurrence.

Conclusion:

In patients who develop fever and elevated inflammatory markers following granulocyte colony-stimulating factor administration, granulocyte colony-stimulating factor-related aortitis should be considered in the differential diagnosis.

キーワード:

大動脈炎顆粒球コロニー刺激因子ペグフィルグラスチム前立腺がんステロイド

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