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Updated: Jan 7, 2026

Efficient Synthesis of All-Carbon Quaternary Centers via the Conjugate Addition of Functionalized Monoorganozinc Bromides

Efficient Synthesis of All-Carbon Quaternary Centers via the Conjugate Addition of Functionalized Monoorganozinc Bromides

Published on: May 26, 2019

アルコール脱水反応によるオレフィン合成のための先進触媒：キノリン縮合オキサゾリジン含有(II)銅錯体

Aurodeep Panda¹, Ruilin Zhang¹, William W Brennessel¹

¹Department of Chemistry, University of Rochester, Rochester, New York 14627, United States.

The Journal of organic chemistry

|December 31, 2025

Abstract:

The new copper(II) catalyst [Cu(^QFOX)(CH₃CN)][OTf]₂ has been synthesized and found to be active for alcohol dehydration to give olefins at 120 °C with a 1% catalyst loading (^QFOX = di-2-quinolinyl-fused-oxazolidine). Benzylic, allylic, and tertiary alcohols are all dehydrated. In some cases, ethers are observed to be produced, but these are re-entrained into the catalytic cycle. Unactivated secondary alcohols are also dehydrated. Similar catalysts employing Mn^II, Fe^II, Co^II, and Ni^II were also synthesized but showed reduced dehydration activity compared to the copper(II) derivative. A Cu^I analog was also prepared but did not show improved dehydration activity.

キーワード:

アルコール脱水オレフィン合成銅触媒キノリン縮合オキサゾリジン有機合成

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