Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Cross-reactivity00:42

Cross-reactivity

32.8K
Overview
32.8K
Vaccinations01:51

Vaccinations

51.1K
Overview
51.1K
Diversity of Antigen Receptors01:28

Diversity of Antigen Receptors

1.3K
Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
1.3K
Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

1.2K
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
1.2K
Pneumonia III: Complications and Assessment01:30

Pneumonia III: Complications and Assessment

756
Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
756
Immunological Memory01:23

Immunological Memory

14.9K
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
14.9K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Comparison of Vaccine Adverse Events Between Zoster Vaccine Live and Recombinant Zoster Vaccine: A Prospective Multicenter Survey.

Journal of Korean medical science·2026
Same author

Limited protective immunity to respiratory syncytial virus and pertussis among adults and healthcare workers in South Korea: A seroepidemiologic study.

Human vaccines & immunotherapeutics·2026
Same author

Development and Validation of Sixplexed Opsonophagocytic Killing Assay for Serotype-Specific Functional Pneumococcal Antibody Measurement.

Vaccines·2026
Same author

Epitope-Based Multimeric Subunit Vaccine (ATOMSSUISpenta) Confers Broad Protection Against Streptococcus suis Infection.

The Journal of infectious diseases·2026
Same author

Real-World Effectiveness of Seasonal Influenza Vaccines During the 2024-2025 Season: Subgroup Analyses by Virus Subtype, Time Since Vaccination, and Diagnostic Method.

Vaccines·2026
Same author

Establishing an Active Vaccine Safety Surveillance System Using Large Scale Databases in Korea: Lessons and Scalable Insights for Global Application.

Journal of Korean medical science·2026

関連する実験動画

Updated: Jan 7, 2026

Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria
11:32

Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria

Published on: February 23, 2014

15.5K

肺炎球菌血清群内の交差反応性免疫：次世代ワクチン開発への示唆

A-Yeung Jang1, Hyun Jung Ji2, Eun Hye Kang3

  • 1Division of Infectious Disease, Department of Internal Medicine, Korea University College of Medicine, Seoul, Republic of Korea; Vaccine Innovation Center-KU Medicine (VIC-K), Seoul, Republic of Korea.

Vaccine
|December 31, 2025
PubMed
まとめ

肺炎球菌ワクチンは、血清群内で多様な交差反応性免疫を誘導する。6A血清群が6B/6Cを保護するようなパターンを理解することが、次世代肺炎球菌ワクチンの設計の鍵となる。

キーワード:
交差反応性免疫原性肺炎球菌ワクチン肺炎球菌血清群血清型置換

さらに関連する動画

Capsular Serotyping of Streptococcus pneumoniae by Latex Agglutination
09:11

Capsular Serotyping of Streptococcus pneumoniae by Latex Agglutination

Published on: September 25, 2014

22.5K
Capsular Serotyping of Streptococcus pneumoniae Using the Quellung Reaction
04:25

Capsular Serotyping of Streptococcus pneumoniae Using the Quellung Reaction

Published on: February 24, 2014

46.5K

関連する実験動画

Last Updated: Jan 7, 2026

Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria
11:32

Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria

Published on: February 23, 2014

15.5K
Capsular Serotyping of Streptococcus pneumoniae by Latex Agglutination
09:11

Capsular Serotyping of Streptococcus pneumoniae by Latex Agglutination

Published on: September 25, 2014

22.5K
Capsular Serotyping of Streptococcus pneumoniae Using the Quellung Reaction
04:25

Capsular Serotyping of Streptococcus pneumoniae Using the Quellung Reaction

Published on: February 24, 2014

46.5K

科学分野:

  • 免疫学; ワクチン学; 微生物学

背景:

  • 肺炎球菌血清型置換ダイナミクスはワクチン有効性に影響を与える。; 交差反応性免疫の理解は、次世代肺炎球菌ワクチン設計にとって重要である。

研究 の 目的:

  • 阻害オプトファゴサイトーシスアッセイ（OPA）を用いた肺炎球菌血清型間の交差反応性免疫を調査すること。; 血清型置換ダイナミクスに関する免疫学的洞察を提供すること。

主な方法:

  • PCV13/PPSV23、PCV20、またはPCV21でワクチン接種を受けた40歳以上の成人から得られたプールした血清を使用した。; 同種または異種不活化肺炎球菌株による吸着後の残存OPA力価を測定することにより、血清群6、9、15、19、および23における交差反応性を評価した。

主要な成果:

  • 交差反応性は血清群によって著しく異なった。; 6A血清群は6Bおよび6Cに対する広範な交差防御を示したが、6Dは同種反応性のみを示した。; 阻害OPAは、15血清群内での一貫性のない交差反応性、および19Aと19F間の部分的で非対称な交差反応性を明らかにした。; 9血清群と23血清群は、無視できるほどの交差反応性を示した。

結論:

  • 阻害OPAは血清群レベルの交差反応性免疫を正確に評価し、不均一なパターンを強調した。; この発見は、将来の肺炎球菌ワクチン開発における慎重な血清型選択とエピトープ評価の必要性を強調している。