ポリスチレンマイクロプラスチックはゼブラフィッシュの初期発生段階におけるビスフェノールAの毒性効果を調節する
Alessandra La Pietra1, Teresa Mobilio1, Gianluca Fasciolo1
1Department of Biology, University of Naples Federico II, Naples, Italy.
Abstract:
One of the characteristics of polystyrene microplastics (PS-MPs) is their hydrophobic surface, which allows them to carry other pollutants such as bisphenol A (BPA), known to be endocrine disruptor. This study investigated the co-exposure of 1µm PS-MPs at 1.0 mgL-1 with BPA at 25.0µM on zebrafish development. The results on the toxicity parameters showed that PS-MPs and BPA during co-exposure had antagonist effects reducing their effects compared to single exposure, in hatching, neurotoxicity and heart rate. This trend was confirmed by an improvement in the expression of developmental genes observed in the co-exposed group. However, in redox homeostasis analysis emerged that, when together, PS-MPs exacerbated the effects of BPA compared to single exposure in redox homeostasis analysis. The findings showed a dual role of PS-MPs in modulating the effects of BPA providing new information on the risk associated with their simultaneous presence in the aquatic environment.
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