AI駆動型超解像顕微鏡：ナノスケール細胞イメージングにおける革命

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Updated: Jan 7, 2026

Super-Resolution Live Cell Imaging of Subcellular Structures

Super-Resolution Live Cell Imaging of Subcellular Structures

Published on: January 13, 2021

Sen Li^1,2, Xiangjie Meng^1,2, Bo Zhou³

¹School of Biomedical Engineering, Harbin Institute of Technology (Shenzhen), Shenzhen, China.

|December 31, 2025

Abstract:

Super-resolution microscopy (SRM) has revolutionized nanoscale cellular imaging, providing detailed insights into cellular architecture, organelle organization, molecular interactions and subcellular dynamics. Artificial intelligence (AI) has shown its transformative potential for improving SRM to advance our understanding of complex cellular structures and dynamics. This Review begins by offering a comprehensive overview of AI techniques in computer vision, focusing on their application to SRM. Additionally, this Review provides a thorough summary of publicly available code and datasets that can support the development and evaluation of AI-empowered SRM. Notably, many AI techniques in the domain of computer vision remain underexplored in SRM. The ongoing evolution of AI promises to unlock new potential in SRM, and the integration of cutting-edge AI technologies is poised to pioneer breakthroughs in nanoscale cellular imaging.

キーワード:

人工知能超解像顕微鏡細胞イメージングコンピュータビジョンナノスケールイメージング

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Ground State Depletion Super-resolution Imaging in Mammalian Cells

Ground State Depletion Super-resolution Imaging in Mammalian Cells

Published on: November 5, 2017

Confocal and Super-Resolution Imaging of Polarized Intracellular Trafficking and Secretion of Basement Membrane Proteins During Drosophila Oogenesis

Confocal and Super-Resolution Imaging of Polarized Intracellular Trafficking and Secretion of Basement Membrane Proteins During Drosophila Oogenesis

Published on: May 19, 2022

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Super-resolution Fluorescence Microscopy

Super-resolution Fluorescence Microscopy

Super-resolution fluorescence microscopy (SRFM) provides a better resolution than conventional fluorescence microscopy by reducing the point spread function (PSF). PSF is the light intensity distribution from a point that causes it to appear blurred. Due to PSF, each fluorescing point appears bigger than its actual size, and it is the PSF interference of nearby fluorophores that causes the blurred image. Various approaches to achieving higher resolution through SRFM have recently been...

Overview of Electron Microscopy

Overview of Electron Microscopy

The wavelengths of visible light ultimately limit the maximum theoretical resolution of images created by light microscopes. Most light microscopes can only magnify 1000X, and a few can magnify up to 1500X. Electrons, like electromagnetic radiation, can behave like waves, but with wavelengths of 0.005 nm, they produce significantly greater resolution up to 0.05 nm as compared to 500 nm for visible light. An electron microscope (EM) can create a sharp image that is magnified up to 2,000,000X.