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Updated: Jan 7, 2026

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents

Published on: May 28, 2014

プリン塩基アルカロイドおよび核酸塩基に対する白金系薬剤の比較結合親和性

Beata Szefler¹, Kamil Szupryczyński²

¹Department of Physical Chemistry, Faculty of Pharmacy, Collegium Medicum, Nicolaus Copernicus University, Kurpińskiego 5 Street, 85-096 Bydgoszcz, Poland.

|January 1, 2026

Abstract:

Platinum-based anticancer drugs are among the most commonly used agents in cancer therapy. In particular, carboplatin, cisplatin, and oxaliplatin have been used in both monotherapies and combination therapies for many years. The main targets of these compounds are nucleobases in DNA. By creating cross-links, they inhibit cell development and lead to apoptosis. Recent studies indicate that platinum-(II) drugs can interact with other compounds with structures similar to nucleobases. For this reason, the current study analyzed the interactions of carboplatin, cisplatin, and oxaliplatin with nucleobases and purine alkaloids (caffeine, theobromine, theophylline) using spectroscopic and computational chemistry methods. Theoretical studies indicated that cytostatics exhibit affinity not only for nucleobases but also for purine alkaloids. However, cytostatics more easily form complexes with nucleobases compared with alkaloids. Experimental investigations confirmed the results of these theoretical studies.

キーワード:

白金系薬剤核酸塩基プリンアルカロイド結合親和性計算化学分光法

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Mapping the Binding Site of an Aptamer on ATP Using MicroScale Thermophoresis

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Genome-wide Mapping of Drug-DNA Interactions in Cells with COSMIC Crosslinking of Small Molecules to Isolate Chromatin

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Published on: January 20, 2016

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